Study on Surgical Treatment Strategies for Moderate Ischemic Mitral Regurgitation

NCT06408779 — Completed, 464 participants, China National Center for Cardiovascular Diseases

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Registry	NCT06408779
Status	Completed
Study type	Observational
Enrollment	464 (Actual)
Sponsor	China National Center for Cardiovascular Diseases (Other gov)
Conditions	Mitral Valve Insufficiency, Mitral Valve Annuloplasty, Coronary Artery Bypass
Interventions	mitral valve repair (Procedure)
Dates	start 2023-08-01, primary completion 2024-04-01, completion 2024-04-01, first posted 2024-05-10, last updated 2024-05-16
Locations	1 site in China

-Summary

This study aimed to compare the efficacy of isolated coronary artery bypass grafting and coronary artery bypass grafting + mitral valve repair in moderate ischemic mitral regurgitation patients through a cohort and explore the potential risk factors of the clinical outcomes.

Expand all sections · Collapse all

+Arms and interventions

Arm	Type	Interventions	Description
coronary artery bypass grafting		Procedure: mitral valve repair
coronary artery bypass grafting concomitant mitral valve repair		Procedure: mitral valve repair

mitral valve repair (Procedure): coronary artery bypass grafting concomitant mitral valve repair

+Outcome measures

Primary outcomes

major adverse cardiovascular and cerebrovascular events [2years]: the composite of all-cause death, rehospitalization for heart failure, non-fatal myocardial infarction, non-fatal stroke or repeat mitral valve surgery.

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

1. Adult coronary artery disease patients complicated with moderate ischemic mitral regurgitation.
2. undergoing coronary artery bypass grafting with or without mitral valve repair.

Exclusion Criteria:

1. patients under the age of 18 years,
2. patients complicated with more than moderate ischemic mitral regurgitation or undergoing mitral valve replacement,
3. patients complicated with primary mitral valve disease other than ischemic mitral regurgitation, such as rheumatic mitral regurgitation or mitral valve leaflet prolapse,
4. patients undergoing concomitant aortic valve procedure.

+Locations (1)

Facility	City	Country	Status
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College	Beijing	China