Effect of Dexmedetomidine on Oxygenation and Lung Mechanics

NCT06355960 — Not applicable, Unknown, 176 participants, Cairo University

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Effect of Different Does of Dexmedetomidine on Oxygenation and Lung Mechanics

Registry	NCT06355960
Status	Unknown
Phase	Not applicable
Study type	Interventional; randomized, parallel, masking: quadruple, treatment
Enrollment	176 (Estimated)
Sponsor	Cairo University (Other)
Conditions	Drug Use, Dexmedetomidine
Interventions	GROUP Dexmedetomidine, GROUP B, GROUP C (Drug)
Dates	start 2024-04-01 (estimated), primary completion 2025-04-01 (estimated), completion 2025-05-01 (estimated), first posted 2024-04-10, last updated 2024-04-10
Locations	1 site in Egypt

-Summary

Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation

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+Arms and interventions

Arm	Type	Interventions	Description
group A	Active comparator	Drug: GROUP Dexmedetomidine	Dexmedetomidine (Precedex) loadings of 1 μg/kg than continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
group B	Active comparator	Drug: GROUP B	Dexmedetomidine (Precedex) loadings of 0.5 μg/kg then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
group C	Active comparator	Drug: GROUP C	Dexmedetomidine (Precedex) loadings of 0.25 μg/kg(group C) then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .

GROUP Dexmedetomidine (Drug): Dexmedetomidine (Precedex) loadings of 1 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
GROUP B (Drug): Dexmedetomidine (Precedex) loadings of 0.5 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
GROUP C (Drug): Dexmedetomidine (Precedex) loadings of 0.25 μg/kg, then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .

+Outcome measures

Primary outcomes

Oxygenation by the end study [UP TO 6 HOURE]: PaO2/Fraction of inspired oxygen

Secondary outcomes

Intraoperative dynamic lung compliance [up to 6 hours]: tidal volume/ (peak airway pressure -PEEP)
Intraoperative static lung compliance [UP TO 6 HOURE]: Tidal volume/ (plateau pressure - PEEP)
Physiological dead space [UP TO 6HOURE]: 1.14 (PaCO2-EtCO2)/ PaCO2-0.005

+Eligibility

Sex: All, ages: 18 Years to any, accepts healthy volunteers

Inclusion Criteria:

Morbidly obese patients with restrictive lung disease ASA I AND II laparoscopic sleeve gastrectomy

Exclusion Criteria:

history of heart failure history of cardiac arrhythmias severe liver or kidney impairment. Patients with forced expiratory volume in 1 sec (FEV1)/ FVC < 70%

+Locations (1)

Facility	City	Country	Status
Cairo university	Cairo	Egypt

+Investigators

Amr s wahdan, MD, Principal investigator, Cairo university , Cairo, Egypt