Adapting Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief: The MORE Relief Trial
| Registry | NCT05877521 |
|---|---|
| Status | Active not recruiting |
| Phase | Phase 2 |
| Study type | Interventional; randomized, parallel, masking: none, treatment |
| Enrollment | 76 (Actual) |
| Sponsor | Memorial Sloan Kettering Cancer Center (Other) |
| Conditions | Chronic Pain, Cancer Pain |
| Interventions | MORE treatments, Standard of Care for Pain Management (Behavioral, other) |
| Dates | start 2023-05-16, primary completion 2027-05-16 (estimated), completion 2027-05-16 (estimated), first posted 2023-05-26, last updated 2026-09-25 |
| Locations | 1 site in United States |
Related Papers Related Patents Related Grants Related Experts
All trials for Chronic Pain All trials for Cancer Pain All trials of MORE treatments All trials of Standard of Care for Pain Management
The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Wait List Control (WLC) Usual Care Procedure | Placebo comparator | Other: Standard of Care for Pain Management | Participants in the WLC group continue to receive their standard medical care and pain management as prescribed by their physicians or other health care providers. |
| 16-hour MORE treatments | Experimental | Behavioral: MORE treatments | Patients in the 16-hour MORE format will receive one 2hrs treatment a week for 8 consecutive weeks (as per study schema: from week 1 to week 8). |
| 8-hour MORE treatments | Experimental | Behavioral: MORE treatments | Patients in the 8-hour MORE format will receive one 2hrs treatment a week for 4 consecutive weeks (as per study schema: from week 1 to week 4). |
| 2-hour MORE treatments | Experimental | Behavioral: MORE treatments | Patients in the 2-hour MORE format will receive one 2hrs treatment (as per study schema: in week 1). |
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria: * English speaking * Age ≥ 18 years or older * A history of cancer with no restrictions placed on type of cancer * Determined to be either no-evidence of disease or stable oncological disease by referring or study physicians/advanced practice providers * Having a pain (musculoskeletal, generalized, or neuropathic) rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week * Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days * Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MORE or WLC * Ability to attend video-call session and a quiet/private location Exclusion Criteria: * Active suicidality or schizophrenia * Plan to initiate palliative radiation or interventional pain procedure within the next 12 weeks * Cognitive impairment preventing completing PRO independently or participate in virtual MORE as evaluated by study clinicians
| Facility | City | Country | Status |
|---|---|---|---|
| Memorial Sloan Kettering Cancer Center (All Protocol Activities) | New York, New York | United States |