Metabolic and Infectious Diseases in La Réunion (the REUNION Population-based Study)

NCT05400824 — Recruiting, 2000 participants, Institut National de la Santé Et de la Recherche Médicale, France

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Pathologies métaboliques et Infectieuses en Population générale à La Réunion : étude REUNION

Registry	NCT05400824
Status	Recruiting
Study type	Observational
Enrollment	2000 (Estimated)
Sponsor	Institut National de la Santé Et de la Recherche Médicale, France (Other gov)
Conditions	Infectious Disease, Cardiovascular Diseases, General Population, Metabolic Disease
Interventions	Blood, DNA, feces, urine, hair and skin microbiota collection (Diagnostic test)
Dates	start 2022-05-01, primary completion 2027-12-01 (estimated), completion 2027-12-01 (estimated), first posted 2022-06-02, last updated 2026-07-10
Locations	1 site in France

-Summary

The aim of the present study is to determine the prevalence of cardiometabolic and infectious disease in La Reunion (french oversea department and region of France).

Known or suspected risk factor for these diseases will also be assessed, such as microbiota, cognitive impairement, social inequalities, and genetics.

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+Detailed description

Overall, 2000 men and women will be recruited during two years for an extensive clinical examination including a microbiota, blood, hair and DNA collection, cognitive tests, autonomous nervous system assessment, spirometry, pulse wave velocity measurement, a carotid doppler echo tracking.

+Arms and interventions

Arm	Type	Interventions	Description
general population		Diagnostic Test: Blood, DNA, feces, urine, hair and skin microbiota collection	Observational study of 2000 adult men and women from the general population who will benefit from a free extensive health check up in La Reunion

Blood, DNA, feces, urine, hair and skin microbiota collection (Diagnostic test), also known as Ewing test, Spirometry, EKG, cognitive, anxiety and depression tests, carotid ultrasound, pulse wave velocity measurement, ankle brachial index measurement: See above

+Outcome measures

Primary outcomes

Prevalence of cardiometabolic diseases [cross sectional (at inclusion)]: Prevalence rates for diabetes, hypertension, obesity, dyslipidemia, smoking and subclinical atherosclerosis markers
Prevalence of infectious diseases [cross sectional (at inclusion)]: Seroprevalence rates for chikungunya, dengue, zika, covid19

+Eligibility

Sex: All, ages: 18 Years to 67 Years

Inclusion Criteria:

* 18-67 years
* given consent for genetic analysis,
* written consent for participating in the study

Exclusion Criteria:

* judicial protection or guardianship

+Locations (1)

Facility	City	Country	Status
Centre Hospitalier Universitaire de La Réunion	La Réunion, Saint-Pierre	France	Recruiting

+Investigators

Maxime COURNOT, MD, PhD, Principal investigator, Institut National de la Santé Et de la Recherche Médicale, France
Olivier MEILHAC, PhD, Study director, Institut National de la Santé Et de la Recherche Médicale, France
Patrick MAVINGUI, PhD, Study director, Institut National de la Santé Et de la Recherche Médicale, France