Safety and Feasibility of Reversible Induction Strategy

NCT04434963 — Unknown, 20 participants, RenJi Hospital

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Safety and Feasibility of Reversible Induction Strategy Supported by HFNC Combined With Specific Anesthetic

Registry	NCT04434963
Status	Unknown
Study type	Observational
Enrollment	20 (Estimated)
Sponsor	RenJi Hospital (Other)
Conditions	Patients With Uncertain Difficult Airway, Colon Cancer, Gastric Cancer, Prostatic Cancer
Dates	start 2021-02-01, primary completion 2021-12-01 (estimated), completion 2021-12-01 (estimated), first posted 2020-06-17, last updated 2021-09-14
Locations	1 site in China

-Summary

This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term effect anesthetic including Propofol and Remifentanil for sedation and analgesia and Sugammadex would be used for reverse the muscle relaxant.

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+Outcome measures

Primary outcomes

Successful rate of reversion [From the beginning of induction to 15min later]

Secondary outcomes

TOFr 0.9 reversion time [From the beginning of induction to 15min later]
BIS 80 reversion time [From the beginning of induction to 15min later]
Tidal volume 6-8ml tidal volume 6-8ml/kg reversion time [From the beginning of induction to 15min later]
consciousness reversion time [From the beginning of induction to 15min later]

+Eligibility

Sex: All, ages: 18 Years to 65 Years

Inclusion Criteria:

* >18 years old,<65 years old
* Signed informed consent
* Undergoing selective operation （ time of operation is over two hours）
* ASA classification I-II
* Mallampati classification 3-4
* suspicious difficult airway, but the anesthetists decide to try to rapid induction

Exclusion Criteria:

* Patients with several dysfunctions of liver, kidney or heart)
* Patients with a full stomach or have other risk factors of reflux aspiration
* Any medicine was taken before surgery, which might enhance or mitigate the effects of muscle relaxant
* Infection of the mouth or nose
* Allergy history of any medicine which would be used in this study
* Pregnant and lactating women
* Patients with neuromuscular disease

+Locations (1)

Facility	City	Country	Status
Ren Ji Hospital Affliated to School of Medicine, Shanghai Jiao Tong University	Shanghai, Shanghai Municipality	China	Recruiting

+Investigators

diansan su, Study director, Renji Hospital, Shanghai Jiaotong University, Shanghai, China

My Notes

Public

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