AWAITS: A Web-based E-health Application for Active Illicit Opioid Users

The pre-post study of AWAITS will: 1) assess the acceptability of AWAITS as measured by participant feedback about the intervention; 2) test the impact of AWAITS on knowledge about opioid overdose, as measured by the OOTAS; 3) assess the proportion of participants who accept a list of local MAT treatment providers; and 4) test the impact of AWAITS on interest in being tested for HCV/HIV.

The acceptability of AWAITS will be assessed with a feedback form which includes questions about how helpful the intervention was (scale of 1-4), what the patient liked most and least about the intervention, and any suggestions for improving it. The average (and standard deviation) for the rated helpfulness of the intervention will be derived and the qualitative data about what they liked most and least about the intervention and suggestions for improvement will be tabulated. Pre-/post-changes in the percent of correct knowledge assessment items (i.e., about overdose and MAT) and interest in HCV/HIV testing will be analyzed using a Wilcoxon signed-rank test. The proportion of participants accepting a list of local MAT treatment providers will be calculated.

• self-administered, e-health application (Other): AWAITS is a self-administered, e-health application and includes short videos in which patients who are successfully engaged in MAT discuss what they wish they had known about MAT when they were actively using. The intervention is designed to maximize "scalability" - the administration would entail handing an electronic device (e.g., tablet, laptop, etc.) to an individual who would then self-administer the intervention.

Primary outcomes

• 3 sections of the OOTAS (signs of overdose, how to respond to an overdose, and MAT) [Day 1]: To test the impact of AWAITS on knowledge about opioid overdose

Secondary outcomes

• Feedback on AWAITS [Day 1]: To assess the acceptability of the intervention
• Acceptance of list of MAT providers [Day 1]: Assess relative interest in MAT post-AWAITS

Sex: All, ages: 18 Years to any

Inclusion Criteria:

1. At least 18 years of age
2. Not enrolled in MAT per self-report
3. Self-reports illicit opioid use

Exclusion Criteria:

3\. Does not acknowledge reviewing "Information Sheet for Research" within REDCap

• Theresa Winhusen, PhD, Principal investigator, University of Cincinnati