Evaluation of Novel Lung Function Parameters and Quantitative Computed Tomography (qCT) in Patients With Pulmonary Disease

NCT02826265 — Unknown, 100 participants, Universitätsmedizin Mannheim
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RegistryNCT02826265
StatusUnknown
Study typeObservational
Enrollment100 (Estimated)
SponsorUniversitätsmedizin Mannheim (Other)
ConditionsChronic Obstructive Pulmonary Disease, Bronchial Asthma, Interstitial Lung Disease
Interventionsmultiple breath washout test (MBW), impulse oscillometry (IOS), body plethysmography (BP), quantitative computed tomography (qCT) (Device)
Datesstart 2016-01-01, primary completion 2020-12-01 (estimated), completion 2020-12-01 (estimated), first posted 2016-07-07, last updated 2020-03-24
Locations1 site in Germany

Related Papers Related Patents Related Grants Related Experts
All trials for Chronic Obstructive Pulmonary Disease All trials for Bronchial Asthma All trials of multiple breath washout test (MBW) All trials of impulse oscillometry (IOS)

-Summary

Current diagnostic tools used in pulmonary disease often do not meet the challenges set by the respective pathophysiology. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and therapeutic monitoring of patients with various pulmonary diseases.

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+Arms and interventions

ArmTypeInterventionsDescription
pulmonary diseaseDevice: multiple breath washout test (MBW); Device: impulse oscillometry (IOS); Device: body plethysmography (BP); Device: quantitative computed tomography (qCT)patients with known or suspected pulmonary disease
  • multiple breath washout test (MBW) (Device)
  • impulse oscillometry (IOS) (Device)
  • body plethysmography (BP) (Device)
  • quantitative computed tomography (qCT) (Device): ultra-low-dose qCT

+Outcome measures

Primary outcomes

  • correlation of lung clearance index (LCI) as determined by multiple breath washout with emphysema quantification as determined by qCT [2 weeks]
  • correlation of airway resistance and reactance (R5, X5, R-D5-20) as determined by impulse oscillometry with emphysema quantification as determined by qCT [2 weeks]
  • correlation of residual volume and airway resistance as determined by body plethysmography with and emphysema quantification as determined by qCT [2 weeks]

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* known or suspected pulmonary lung disease
* indication for computed tomography

Exclusion Criteria:

* pregnancy
* inability to participate

+Locations (1)

FacilityCityCountryStatus
Universitätsmedizin MannheimMannheimGermanyRecruiting