Glucose and Fructose Stimulated Brain Activity in Obese Subjects

NCT02589613 — Not applicable, Completed, 12 participants, University Hospital, Basel, Switzerland

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Effects of Acute Glucose and Fructose Ingestion on Brain Activity in Obese Volunteers

Registry	NCT02589613
Status	Completed
Phase	Not applicable
Study type	Interventional; randomized, crossover, masking: double, prevention
Enrollment	12 (Actual)
Sponsor	University Hospital, Basel, Switzerland (Other)
Conditions	Exploratory Behavior
Interventions	tap water, Glucose, Fructose (Dietary supplement)
Dates	start 2013-10-01, primary completion 2014-06-01, completion 2014-06-01, first posted 2015-10-28, last updated 2015-10-28

-Summary

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

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+Arms and interventions

Arm	Type	Interventions	Description
PLACEBO	Placebo comparator	Dietary Supplement: tap water	Single intragastric instillation of 300ml tap water via nasogastric tube
GLUCOSE	Active comparator	Dietary Supplement: Glucose	Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube
FRUCTOSE	Active comparator	Dietary Supplement: Fructose	Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube

tap water (Dietary supplement): 300ml tap water via nasogastric tube
Glucose (Dietary supplement): 300ml tap water with 75g Glucose via nasogastric tube
Fructose (Dietary supplement): 300ml tap water with 25g Fructose via nasogastric tube

+Outcome measures

Primary outcomes

Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow [changes from baseline to one hour after treatment]

Secondary outcomes

Changes in plasma insulin [changes from baseline to one hour after treatment]
Changes in plasma glucose [changes from baseline to one hour after treatment]
Changes in plasma GLP-1 [changes from baseline to one hour after treatment]

+Eligibility

Sex: Male, ages: 18 Years to 45 Years, accepts healthy volunteers

Inclusion Criteria:

* right-handed healthy males, no drugs, non-smoking

Exclusion Criteria:

* drug abuse, smoker, left-handed, claustrophobia

+Investigators

Christoph Beglinger, MD, Study chair, University of Basel

My Notes

Public

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