Study of the Neural Basis of Analogical Reasoning

NCT02236832 — Not applicable, Completed, 130 participants, Institut National de la Santé Et de la Recherche Médicale, France

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Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.

Registry	NCT02236832, acronym ANALOG
Status	Completed
Phase	Not applicable
Study type	Interventional; non randomized, crossover, masking: none, basic science
Enrollment	130 (Actual)
Sponsor	Institut National de la Santé Et de la Recherche Médicale, France (Other gov); collaborators: Fondation pour la Recherche Médicale
Conditions	Frontotemporal Dementia, Progressive Supranuclear Palsy, Healthy Subjects
Interventions	transcranial magnetic stimulation, MRI imaging, EEG recording, Neuropsychological examination (Device, other, behavioral)
Dates	start 2015-02-01, primary completion 2021-02-01, completion 2021-02-01, first posted 2014-09-11, last updated 2025-09-04
Locations	1 site in France

-Summary

Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

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+Arms and interventions

Arm	Type	Interventions	Description
FTD (frontotemporal dementia) patients	Experimental	Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination	fronto-temporal demential patients
PSP patients	Experimental	Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination	progressive supra nuclear palsy patients
healthy controls	Active comparator	Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination	healthy control education matched, age matched and sex matched with PSP and FTD patients
healthy participants	Experimental	Device: transcranial magnetic stimulation; Other: MRI imaging; Other: EEG recording; Behavioral: Neuropsychological examination	healthy participants that will participate to the TMS study.
healthy young participants	Experimental	Other: EEG recording; Behavioral: Neuropsychological examination	Healthy participants will be included for an EEG study

transcranial magnetic stimulation (Device)
MRI imaging (Other)
EEG recording (Other)
Neuropsychological examination (Behavioral)

+Outcome measures

Primary outcomes

Performance in the implicat task [day of inclusion (one day)]: Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre.
Performance in the Similitude task [from inclusion to 4 months after inclusion]: Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.

Secondary outcomes

recording of EEG [day of inclusion (one day)]: EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials. Participants will come only once during one day a the research centre.
Analysis of MRI [day of inclusion (one day)]: T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls. Participants will come only once during one day at the research centre

+Eligibility

Sex: All, ages: 20 Years to 85 Years, accepts healthy volunteers

Inclusion Criteria:

Healthy subjects:

* subject affiliated to national health insurance
* informed consent signed
* normal neurological examination
* subject aged at least 20

Patients:

* FTD or PSP diagnostic criteria filled
* patient affiliated to national health insurance
* informed consent signed

Exclusion Criteria:

* Severe psychiatric symptomatology and psychotropic drug use
* unability to understand or perform the cognitive tasks.

+Locations (1)

Facility	City	Country	Status
ICM (Institut du cerveau et de la Moelle épinière)	Paris	France

+Publications

Results publication: Ovando-Tellez M, Rohaut B, George N, Bieth T, Hugueville L, Ibrahim Y, Courbet O, Naccache L, Levy R, Garcin B, Volle E. Does adding beer to coffee enhance the activation of drinks? An ERP study of semantic category priming. Cogn Neurosci. 2022 Jan-Jun;13(2):61-76. doi: 10.1080/17588928.2021.1940117. Epub 2021 Jul 7. PMID 34232829

+Investigators

Richard Levy, MD, PhD, Principal investigator, Institut du Cerveau et de la Moelle épinière, Paris