Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy

NCT01926301 — Withdrawn, Johannes Gutenberg University Mainz
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Cerebrovascular Autoregulation in Patients With Severe Sepsis and Septic Shock, Influence of Renal Replacement Therapy

RegistryNCT01926301, acronym SepsAR2
StatusWithdrawn
Study typeObservational
SponsorJohannes Gutenberg University Mainz (Other)
ConditionsSevere Sepsis, Septic Shock
Interventionscontinuous veno-venous hemodialysis (Procedure)
Datesstart 2013-08-01, primary completion 2020-06-01, completion 2020-06-01, first posted 2013-08-20, last updated 2020-06-11
Locations1 site in Germany

Related Papers Related Patents Related Grants Related Experts
All trials for Severe Sepsis All trials for Septic Shock All trials of continuous veno-venous hemodialysis

-Summary

The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation.

Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.

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+Arms and interventions

ArmTypeInterventionsDescription
HemodialysisProcedure: continuous veno-venous hemodialysisPatients with severe sepsis or septic shock with acute renal failure and requirement of continuous veno-venous hemodialysis
No hemodialysisPatients with severe sepsis or septic shock without acute renal failure and no requirement of continuous veno-venous hemodialysis
  • continuous veno-venous hemodialysis (Procedure), also known as Renal replacement therapy

+Outcome measures

Primary outcomes

  • Cerebrovascular autoregulation [during the first 4 days]: Cerebrovascular autoregulation measured daily at the first 4 days of severe sepsis and septic shock

Secondary outcomes

  • Delirium [at day 4]: Incidence of Delirium at day 4 after severe sepsis or septic shock

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* severe sepsis or septic shock
* adult patients
* possibility of transcranial Doppler ultrasound

Exclusion Criteria:

* traumatic brain injury
* known cerebrovascular diseases
* Infection of the brain
* chronic renal failure
* pregnancy

+Locations (1)

FacilityCityCountryStatus
University Medical Center of the Johannes Gutenberg-UniverityMainzGermany

+Investigators