Biomarker in Tissue Samples From Patients With Ewing Sarcoma

NCT01365949 — Completed, 40 participants, Children's Oncology Group

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INI-1 Deletions in Ewing Sarcoma

Registry	NCT01365949
Status	Completed
Study type	Observational
Enrollment	40 (Estimated)
Sponsor	Children's Oncology Group (Network); collaborators: National Cancer Institute (NCI)
Conditions	Sarcoma
Interventions	microarray analysis, protein analysis, immunohistochemistry staining method, laboratory biomarker analysis (Genetic, other)
Dates	start 2011-05-01, primary completion 2016-07-01, first posted 2011-06-03, last updated 2016-07-11

-Summary

RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies biomarkers in tissue samples from patients with Ewing sarcoma.

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+Detailed description

OBJECTIVES:

* To determine the frequency of INI-1 protein loss in Ewing Sarcoma.

OUTLINE: Previously collected tissue samples are analyzed for INI-1 protein loss by IHC and tissue microarray.

+Arms and interventions

microarray analysis (Genetic)
protein analysis (Genetic)
immunohistochemistry staining method (Other)
laboratory biomarker analysis (Other)

+Outcome measures

Primary outcomes

Frequency of INI1 protein loss in Ewing Sarcoma

+Eligibility

Sex: All, ages: any to 120 Years

DISEASE CHARACTERISTICS:

* Diagnosis of Ewing sarcoma
* Prepared tissue microarray with Ewing sarcoma samples available

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified

+Investigators

Joshua D. Schiffman, MD, Principal investigator, University of Utah