| Registry | NCT00980694 |
|---|---|
| Status | Completed |
| Phase | Phase 1 |
| Study type | Interventional; na, single group, masking: none |
| Enrollment | 6 (Actual) |
| Sponsor | University of Rochester (Other); collaborators: Kaneka Corporation |
| Conditions | Huntington Disease |
| Interventions | ubiquinol (Dietary supplement) |
| Dates | start 2009-09-01, primary completion 2012-07-01, completion 2012-07-01, first posted 2009-09-21, last updated 2016-05-27 |
| Locations | 1 site in United States |
Related Papers Related Patents Related Grants Related Experts
All trials for Huntington Disease All trials of ubiquinol
The death of brain cells in Huntington Disease (HD) is thought to be associated with a lack of normal cell energy and harmful brain substances called free radicals. Coenzyme Q10 (CoQ) is a marketed nutritional supplement that may prove useful in HD because it increases cell energy and combats free radicals.
Most studies of CoQ have looked at only one formulation of CoQ ("ubiquinone") in HD. The purpose of the study is to find out if people that switch from the common formulation of CoQ ("ubiquinone") to a different formulation ("ubiquinol") have higher levels of CoQ in their blood after taking the same dose. The investigators also want to find out if this different formulation is tolerable for individuals with HD.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Ubiquinol | Experimental | Dietary Supplement: ubiquinol | up to 600 mg per day, oral capsules for 8 weeks |
Sex: All, ages: 18 Years to any
Inclusion Criteria: * Have manifest Huntington disease * Be 18 years of age or older * Be taking an oxidized formulation of CoQ for at least 30 days prior to the baseline visit * Be on a steady dose of all concomitant medications for at least 30 days prior to the baseline visit Exclusion Criteria: * Have a history of intolerability of sensitivity to CoQ * Have an unstable medical or psychiatric illness * Be pregnant or breastfeeding; women of childbearing age must use reliable contraception
| Facility | City | Country | Status |
|---|---|---|---|
| University of Rochester | Rochester, New York | United States |