Tissues and Organs Papers of the Week

Hydrogels, possessing three-dimensional network structures, provide a platform for localized drug delivery. Herein, we reported a thermoresponsive polypeptide hydrogel co-loaded with mitoxantrone (MTX) and the angiogenesis inhibitor nintedanib (NE), combined with immune checkpoint blockade therapy, to address these challenges.

Thus, we aimed to evaluate the phytochemical screening and biological activity of the aqueous ethanolic extract of Gc fruit using HPLC, LC-MS, and GC-MS to identify natural phytochemical constituents.

This study aims to explore how atherosclerosis affects NK cell–mediated tumor surveillance in both animal models and humans.

This work proposes a simple and precise co-assembly strategy to construct carrier-free, multifunctional nanotherapeutics, which opens avenues for the concept of self-delivered synergistic PTT agents.

Here, we report the development of a hybrid nanomaterial designed to genetically silence one key regulator, IGFBP2 (insulin-like growth factor binding protein 2), responsible for multicellular crosstalk within the TME.

Methods: We conducted a population-based nested case–control study within a cohort of individuals <40 years old born in California, United States (1982–2017), using linked birth and cancer registry data.

Microcomputed tomography revealed significant trabecular bone deterioration as early as day 11 following orthotopic inoculation, before bone-marrow dissemination became detectable by the clonogenic assay used in this study, with additional alterations in trabecular microarchitecture observed at later stages of tumor progression.

However, the metabolic mechanisms underlying LOXL4-driven CRC progression remain poorly elucidated. This study investigated the biological function of LOXL4 in CRC and its potential as a therapeutic target.

The aim of this study was to establish and apply a framework that combines musculoskeletal modeling with motion capture data to investigate the biomechanics of the human lumbar musculoskeletal system during daily activities.

In this study, the effects of VB on GBM cell viability, clonogenic growth, migration, invasion, EMT-like/mesenchymal transition-associated markers, glioblastoma stem-like cell properties, and senescence-associated changes were examined in U87, U251, and glioblastoma stem-like cells.

Here, we report an ultrasound-driven, bacteria-targeted immunotherapy utilizing polyarginine-functionalized peptide-sonosensitizer conjugates to achieve the in situ pulverization of the tumor Fusobacterium nucleatum (F. nucleatum), thereby eliciting potent innate antitumor immunity.

We consider a phase-field system modeling solid tumor growth.

Here, we report the design and synthesis of a unique class of optically pure, water-soluble, glycosylated Zn(II) metallohelix diastereomers that exhibit exceptional hydrolytic stability and potent, stereochemistry-dependent antiproliferative activity against intrahepatic cholangiocarcinoma (ICC).

Methods A combined disease-syndrome mouse model of SD-type lung cancer cachexia was established using reserpine combined with Lewis lung carcinoma cell inoculation.

Here, we evaluated a dual-tracer PET imaging strategy targeting CD8 + T-cell localization and granzyme B (GZMB)-associated cytotoxic activity during radiotherapy plus PD-1 blockade.

Emerging evidence further implicates autonomic dysfunction, altered connective tissue biomechanics, and neuroimmune interactions in gastrointestinal dysmotility and related gut-brain axis disturbances in EDS. This review highlights these emerging connections alongside the broader neurologic spectrum of EDS.

This study investigated the antitumor effects of DT and the contribution of the ENO1-lactate axis to tumor immune regulation.