Biochemistry Papers of the Week

Herein, we constructed photosynthesis-empowered cross-kingdom chimeric stem cells (PCSs; "mitochondrial battery") by introducing plant-derived thylakoid-based artificial nuclei plus -encoding messenger RNA (mRNA) into enucleated bone marrow mesenchymal stem cells.

Here we show that the epigenetic regulator BAZ2A drives resistance to CD70-targeted CAR-T therapy by reprogramming tumor lipid metabolism.

Macrophages orchestrate the balance between bone resorption and formation primarily through their M1/M2 polarization states, with M1 macrophages promoting resorption and M2 macrophages supporting formation. This review comprehensively describes how key lipid metabolic pathways, such as fatty acid oxidation (FAO) and cholesterol metabolism, govern this polarization and subsequent bone remodeling.

In C. elegans, Zg I extended lifespan, improved locomotor and physiological fitness, reduced age-associated biomarkers, and enhanced oxidative stress resistance.

Our study reveals a mechanistic link between Th2 inflammation and SG ferroptosis via IL-4-TRIM15-GPX4-ubiquitination signaling, thus offering new insights into SG dysfunction and skin barrier impairment in AD.

Our work defines the evolutionarily conserved AMPK-ALDH7A1-KDM5C axis and establishes acetate as a dual regulator of mitochondrial metabolism and anti-tumor immunity, offering therapeutic strategies for targeting metabolic vulnerabilities in HCC.

Large cohort studies associate physical activity with reduced cancer incidence and mortality, and a Phase 3 randomized trial now demonstrates cancer-specific survival benefits of structured exercise.

Here we show that SMARCAL1 forms nuclear condensates via liquid-liquid phase separation to enhance histone H4 lactylation and chromatin accessibility.

However, its physiological roles beyond enzymatic suppression in the nucleus remain poorly understood. Here, we present a genome-wide map of cGAS chromatin localization in human cells and unexpectedly find its binding beyond nucleosome tethering, where cGAS is recruited to chromatin by AP-1 transcription factors via a potentially previously uncharacterized transactivation domain.

We identify that the oxysterol 7α,25-dihydroxycholesterol (7α,25-OHC), produced by Vimentin stromal cells, acts through GPR183 to promote T differentiation and suppressive identity.

Here, we employed an integrated multi-omics approach in a spared nerve injury (SNI) rat model to investigate the gut-metabolite-brain mechanisms underlying EA's efficacy.

Here, using a genome-wide CRISPR screen, we identify UDP-galactose 4-epimerase (GALE) as a tumor-intrinsic checkpoint that restricts Vγ9Vδ2 T cell-mediated killing.

Here, we demonstrated that chronic stress elevates lactate levels in the tumor microenvironment, thereby promoting lactylation of metastasis associated 1 family member 2 (MTA2) at lysine 460.

Here we find that glucose-derived carbon is oxidized in mouse myocardium even when the MPC is genetically ablated.

Mounting evidence identifies mitochondrial dysfunction as a central contributor to neuronal damage and progressive brain functional decline. As a narrative review, this work aims to dissect mitochondrial‑associated pathological features across these major neurodegenerative disorders, summarize under‑recognized emerging mechanisms, and highlight translational bottlenecks for mitochondrial‑targeted therapies.

Here, we show that senescent cells increase import and membrane levels of multiple polyunsaturated fatty acids (PUFAs), but a specific intermediate PUFA, dihomo-gamma-linolenic acid (DGLA, 20:3ω-6), is reduced.

Here, we identify intrinsically disordered antimicrobial peptides, generated from the Drosophila sleep-inducing protein Nemuri, that inhibit bacterial growth by targeting ribosomal organization.

In this study, we explore how NRF2 modulates stress granule dynamics under oxidative and non-oxidative stress conditions.