4 completed, 2 recruiting. 2 Phase 3, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 2 | Completed 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trientine Tetrahydrochloride Administered Once a Day for the First Line Treatment of Wilson's Disease Patients. TETA 4HCl formulation, D-Penicillamine - Wilson's Disease | Phase 3 | Recruiting | Orphalan | 38 | 2026-09-03 | 2026-10-15 |
| Patient Preference Study: Standard of Care Versus Once-daily Trientine Tetrahydrochloride New TETA 4HCl Formulation, Standard of Care - Wilson's Disease | Phase 2 | Completed | Orphalan | 10 | 2025-07-15 | 2026-04-06 |
| Study Comparing Once Daily Dose of 900mg of TETA 4HCL Against Cuprior® (450mg Trientine Base, Twice Daily). 900mg TETA 4HCl Once Daily Formulation, 900mg TETA 4HCl Cuprior® - Wilson's Disease | Phase 1 | Completed | Orphalan | 26 | 2024-01-16 | 2026-08-26 |
| Real World Evidence Study in Subjects With Wilson's Disease NCC-Sp Assay - Wilson Disease | Completed | Orphalan | 50 | 2023-06-28 | 2026-04-06 | |
| International Wilson's Disease Patient Registry (iWilson Registry) Wilson's Disease | Recruiting | Orphalan | 500 | 2022-06-29 | 2026-08-11 | |
| Trientine Tetrahydrochloride (TETA 4HCL) for the Treatment of Wilson's Disease Penicillamine (D1-W12), TETA 4HCL (W12-60), Penicillamine (W12-W60) - Wilson Disease | Phase 3 | Completed | Orphalan | 77 | 2018-09-03 | 2025-07-02 |
Hepatolenticular Degeneration (6)
Penicillamine (2) · Standard of Care (1)
United Kingdom (4) · United States (3) · Belgium (2) · France (2) · Germany (2) · Poland (2) · Saudi Arabia (2) · Brazil (1) · China (1) · Denmark (1) · Italy (1) · Pakistan (1) · Spain (1)
Anna Davidsson (1) · Mike Schilsky (1) · Pramod Mistry, PhD (1) · Thomas Ashdown, MBBCh Ssc (1)