35 completed, 1 terminated, 1 withdrawn. 20 Phase 2, 4 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 20 | Completed 19, Withdrawn 1 |
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 3 | Completed 2, Withdrawn 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Grass-SPIRE Registration Study Grass-SPIRE, Placebo - Rhinitis, Conjunctivitis | Phase 2 / Phase 3 | Withdrawn | Circassia Limited | 2016-05-01 | 2016-06-23 | |
| Observational Analysis of T Cell Responses to SPIREs for Multiple Allergens in Subjects With Allergy in North America Blood Sampling - Allergy | Terminated | Adiga Life Sciences, Inc. | 199 | 2015-10-01 | 2019-04-09 | |
| Birch-SPIRE Safety and Efficacy Study Birch-SPIRE, Placebo - Rhinitis | Phase 2 | Completed | Circassia Limited | 64 | 2015-07-01 | 2016-11-08 |
| Ragweed-SPIRE Follow-On Study Rhinoconjunctivitis, Ragweed Allergy | Completed | Circassia Limited | 249 | 2015-04-01 | 2016-03-23 | |
| A Randomized Prospective Clinical Trial of Fel d 1 Peptide Immunotherapy Cat-PAD, Placebo - Cat Allergy, Cat Hypersensitivity | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 39 | 2015-03-09 | 2018-11-02 |
| Phase II HDM-SPIRE Safety and Efficacy Study HDM-SPIRE, Placebo - Rhinoconjunctivitis | Phase 2 | Completed | Circassia Limited | 715 | 2014-09-01 | 2018-06-15 |
| ToleroMune Grass Follow on Study Rhinoconjunctivitis, Grass Allergy | Completed | Circassia Limited | 84 | 2014-04-01 | 2014-11-17 | |
| Study of Grass-SPIRE in Subjects With Grass Allergies and Asthma Grass-SPIRE, Placebo - Seasonal Allergic Rhinitis, Asthma | Phase 2 | Completed | Circassia Limited | 54 | 2014-04-01 | 2015-03-24 |
| Grass Observational Study Grass Allergy, Rhinoconjunctivitis | Completed | Circassia Limited | 109 | 2014-04-01 | 2015-04-08 | |
| Phase III Cat-PAD Follow-on Study Received Cat-PAD Treatment 1 in Study CP007 [NCT01620762], Received Cat-PAD Treatment 2 in Study CP007 [NCT01620762], Received Cat-PAD Treatment 3 in Study CP007 [NCT01620762] - Cat Allergy | Phase 3 | Completed | Circassia Limited | 430 | 2014-02-01 | 2018-06-15 |
| Evaluating the Efficacy of Ragweed-SPIRE Following Exposure to Ragweed Allergen in an Environmental Exposure Chamber Ragweed-SPIRE, Placebo - Seasonal Allergic Rhinitis | Phase 2 | Completed | Circassia Limited | 280 | 2014-01-01 | 2015-03-20 |
| Safety Study of Ragweed-SPIRE in Subjects With Ragweed Allergies and Asthma Ragweed-SPIRE, Placebo - Seasonal Allergic Rhinitis, Asthma | Phase 2 | Completed | Circassia Limited | 55 | 2014-01-01 | 2015-01-21 |
| House Dust Mite Observational Study Rhinoconjunctivitis | Completed | Circassia Limited | 100 | 2013-09-01 | 2014-05-15 | |
| An Optional Investigation of Biomarkers of Efficacy Rhinoconjunctivitis | Completed | Circassia Limited | 105 | 2013-09-01 | 2014-05-21 | |
| ToleroMune House Dust Mite (HDM) Tolerability Study ToleroMune HDM, Placebo - Rhinoconjunctivitis | Phase 2 | Completed | Circassia Limited | 30 | 2013-09-01 | 2014-06-11 |
| ToleroMune House Dust Mite Follow on Study House Dust Mite Allergy, Rhinoconjunctivitis | Completed | Circassia Limited | 105 | 2013-09-01 | 2014-05-15 | |
| Paediatric Safety Study in Cat-PAD Cat-PAD, Placebo - Rhinoconjunctivitis | Phase 2 | Completed | Circassia Limited | 16 | 2013-08-01 | 2018-05-14 |
| ToleroMune Grass Follow on Study Grass Allergy, Rhinoconjunctivitis | Completed | Circassia Limited | 163 | 2013-05-01 | 2013-11-26 | |
| Antipsoriatic Effect of a Topical Formulation for the Treatment of Psoriasis Vulgaris SPS4251 Ointment, Placebo, Daivonex® ointment - Psoriasis Vulgaris | Phase 1 | Completed | Circassia Limited | 24 | 2013-03-01 | 2013-07-17 |
| Phase III Cat-PAD Study Cat-PAD, Placebo - Rhinoconjunctivitis | Phase 3 | Completed | Circassia Limited | 1408 | 2012-10-01 | 2018-06-15 |
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Hypersensitivity (9) · Rhinitis (5) · Rhinitis, Allergic, Seasonal (3) · Asthma (2) · Dust Mite Allergy (2) · Conjunctivitis (1)
Blood Specimen Collection (1) · calcipotriene (1)
Canada (27) · United States (6) · Germany (4) · Poland (2) · Argentina (1) · Belgium (1) · Chile (1) · Czechia (1) · France (1) · Hungary (1) · Italy (1) · Netherlands (1) · Russia (1) · Slovakia (1) · South Africa (1)
Deepen Patel, MD, CCFP (3) · Jacques Hebert, MD (3) · Peter Couroux, MD (3) · Amarjit Cheema, MD (1) · Anne K Ellis, MD MSC FRCPC (1) · David Bernstein, MD (1) · Deepen Patel, MD (1) · Deepen Patel, MD, CCF (1) · Harold Nelson, MD (1) · Helen Neighbour (1) · Margitta Worm, MD Professor (1) · Piyush Patel, MD (1)
U19AI100266 (1)