AbstractPaper


Molecules (Basel, Switzerland)  ·  2026

HIGHLIGHT
: GC-FID analysis revealed lauric, oleic, and myristic acids as predominant components in the kernel oil.

ABSTRACT
: Herpes simplex virus type 1 (HSV-1) is a global and prevalent pathogen, presenting significant clinical challenges because of its recurring infections, the development of drug resistance and severe clinical complications. This study evaluated the antiviral efficacy against HSV-1 of ( ) kernel oil, a Neotropical palm native to the Americas. : The chemical profile of kernel oil was determined by gas chromatography with flame ionization detection (GC-FID). Antiviral activity was assessed using dose-response curves, time-of-addition assays, and quantification of intracellular viral genomes, viral gene transcripts, and IL-6 expression. kernel oil's antiviral effect was also evaluated using an in vivo HSV-1 cutaneous infection model. : GC-FID analysis revealed lauric, oleic, and myristic acids as predominant components in the kernel oil. kernel oil exhibited potent antiviral activity against HSV-1. The oil inhibited HSV-1 early step post-entry, reducing the mRNA levels of the immediate-early genes ICP4 and ICP22, leading to the downregulation of early and late viral gene expression and intracellular viral genome. Furthermore, the oil suppressed IL-6 expression in infected cells. Importantly, kernel oil promoted the healing of cutaneous lesions in HSV-1-infected mice. : These findings demonstrate that kernel oil is a promising candidate for developing novel antiviral and topical therapies against HSV-1.

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year_of_publication2026
sourceMolecules (Basel, Switzerland)

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