Comparative Genomics of Herpes Simplex Virus 2 Isolated from A Maternal-Neonatal Dyad Reveals High Consensus Sequence Homology As Well As Minor Variant Diversity

Journal of the Pediatric Infectious Diseases Society  ·  2026

Reem Abu Rass; Lacy M Simons; Christopher D Bowen; Haley S Carter; Daniel W Renner; Moriah L Szpara; Lisa N Akhtar;

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ABSTRACT

Neonatal herpes simplex virus disease most often occurs following mother-to-neonate transmission during childbirth. However, genomic differences between the maternal and neonatal viral populations are poorly understood. Here, we performed deep whole-genome sequencing of clinical HSV-2 samples obtained from a maternal-neonatal dyad to investigate viral population dynamics during transmission.

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