Global Pediatric Stroke Epidemiology: A Systematic Review of The Literature and Meta-Analysis

Joseline Haizel-Cobbina; Stefan W Koester; Yusra Arafeh; Prabhat Poudel; Nancy Abu-Bonsrah; Nathan A Shlobin; Jeffrey Chen; Liping Du; Albert Isaacs; Michael C Dewan;

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ABSTRACT

The global burden of stroke in children is poorly characterized. We aimed to quantify the global burden of pediatric stroke. A systematic review and meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The estimated birth prevalence and incidence of perinatal and overall childhood stroke was used to calculate the worldwide stroke burden by World Bank Income Groups and World Health Organization (WHO) regions. The estimated birth prevalence of perinatal stroke (regardless of type) was 21.01 per 100 000 total births and estimated childhood incidence of stroke was 3.73 per 100 000 person-years. The childhood incidence of ischemic stroke and hemorrhagic stroke was 1.30 per 100 000 person-years and 0.99 per 100 000 person-years, respectively. There is a relatively greater burden of perinatal stroke birth prevalence. Epidemiologic data on pediatric stroke is concentrated in western HIC. Coordinated efforts are needed to better understand the burden of pediatric stroke in LMIC.

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