Evaluation of Antimicrobial Activity of Aloe Vera Gel Extract on Hospital-Acquired Methicillin-Resistant Staphylococcus Aureus

Jones Gyamerah; Justice Kumi; Eric N Y Nyarko; Janet Ampofo; Sherif Hamidu; Eunice E Ampem-Danso; Vida Yirenkyiwaa Adjei; Felicia Owusu;

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ABSTRACT

has a long history as a medicinal plant with numerous therapeutic uses. Methicillin-resistant (MRSA) is a type of bacteria resistant to commonly used antibiotics such as penicillin. Hospital-acquired methicillin-resistant (Ha-MRSA) refers to MRSA infections that arise in healthcare settings, usually 48 h or longer after hospital admission or in individuals with recent hospitalization. This research is aimed at investigating the effectiveness of gel extract against Ha-MRSA. The agar well boring diffusion and the broth dilution test methods were employed, respectively, to assess the susceptibility of Ha-MRSA to gel extract in ethanol and DMSO medium. These extraction media were compared for their effectiveness as the solvent of extraction for the susceptibility test. A minimum inhibitory concentration of 0.2 mg/L of gel extract in the ethanolic extraction medium was achieved, indicating susceptibility of the Ha-MRSA strain as recommended by EUCAST/ESCMID. gel ethanol extract was sensitive against Ha-MRSA strains but was resistant in the DMSO extraction method. It is recommended that further research be carried out to ascertain the bioactive compounds responsible for antimicrobial activity.

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