Association of Airway Mucus Plugs and Physical Activity, Exercise Tolerance, Sarcopenia, and Frailty in Patients With COPD and Pre‐COPD

Yusuke Shiraishi; Naoya Tanabe; T. Maetani; Y. Hayashi; Y. Oshima; Yuji Yoshioka; Ryota Hamada; R. Sakamoto; Satoru Terada; A. Sato; S. Sato; T. Hirai;

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ABSTRACT

Airway mucus plugs on computed tomography (CT) are an imaging biomarker of chronic obstructive pulmonary disease (COPD) associated with airflow limitation, respiratory symptoms, and poor prognosis. However, clinical phenotypes relevant to mucus plugs, including sarcopenia and frailty, are not fully elucidated. This study aimed to investigate the association between mucus plugs, sarcopenia, and frailty using a prospective observational COPD‐enriched smoker cohort.

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