Modulation of Neuroinflammation and Nitrite Imbalance in The Hippocampus By Simvastatin: Therapeutic Potential in Maternal Separation‐Induced Autism Spectrum Disorder

M. Ghadiri; Zahra Vahed Dehkordi; Hosein Amini-Khoei;

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ABSTRACT

Autism spectrum disorder (ASD) is an increasingly occurring neurobiological condition. As a main risk factor, maternal separation (MS) stress has a role in the foundation of ASD. Simvastatin possessed neuroprotective effects. We intended to estimate the impact of simvastatin on autism‐related behaviours in mice subjected to the MS paradigm, concentrating on its likely effects on hippocampal oxidative stress imbalance and neuroinflammation.

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