7 completed, 5 unknown, 4 recruiting, 1 not yet recruiting. 8 Phase 2, 4 Not applicable, 3 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Unknown 3, Completed 2, Recruiting 2, Not yet recruiting 1 |
| Not applicable | 4 | Recruiting 2, Completed 1, Unknown 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 4 | 1 | Completed 1 |
Follow Sirtuins: new trials by email Literature Review of Sirtuins trials Research Report on Sirtuins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Yttrium-90 Carbon Microsphere Radioembolization in Previously Treated Hepatocellular Carcinoma NRT6003 Injection - Hepatocellular Carcinoma | Phase 2 | Not yet recruiting | Second Affiliated Hospital of Guangzhou Medical University | 20 | 2026-06-22 | 2026-06-18 |
| SIRT Versus cTACE for Unresectable HCC (CHANCE2506) SIRT, cTACE - Unresectable Hepatocellular Carcinoma | Not applicable | Recruiting | Zhongda Hospital | 108 | 2025-04-03 | 2025-04-09 |
| Lenvatinib Plus SIRT vs Lenvatinib in TACE-Refractory HCC Lenvatinib plus SIRT, Lenvatinib - Hepatocellular Carcinoma Non-resectable | Phase 2 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 78 | 2025-04-01 | 2025-04-29 |
| Y-90 SIRT for Unresectable HCC Larger Than 7cm SIRT - Hepatocellular Carcinoma Non-Resectable | Phase 2 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 33 | 2024-12-01 | 2025-01-28 |
| Efficacy and Safety of 90Y Microsphere Combined With FOLFIRI and Bevacizumab in Second-line Treatment of CRLM SIRT with Yttrium-90 Microspheres, FOLFIRI and Bevacizumab - Colorectal Cancer Metastatic | Unknown | Zhongda Hospital | 30 | 2024-05-20 | 2024-06-07 | |
| SIRT for Potentially Resectable HCC SIRT - Hepatocellular Carcinoma | Not applicable | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 35 | 2023-08-10 | 2023-09-14 |
| Lenvatinib, Sintilimab Plus SIRT for Unresectable HCC Lenvatinib, sintilimab plus SIRT - Hepatocellular Carcinoma | Phase 2 | Unknown | Second Affiliated Hospital of Guangzhou Medical University | 30 | 2023-08-10 | 2023-09-14 |
| Yttrium-90 Carbon Microspheres in Patients With Unresectable Colorectal Liver Metastases Selective internal radiation therapy (SIRT) with yttrium-90 carbon microspheres - Unresectable Colorectal Liver Metastases | Phase 1 / Phase 2 | Unknown | Zhongda Hospital | 60 | 2022-12-28 | 2023-01-30 |
| Evaluating the Effects of Selective Treatment Utilizing Flex-dosing for Unresectable HCC With Y90 SIR-Spheres SIRT with Y-90 resin microspheres - Hepatocellular Carcinoma | Completed | Methodist Health System | 1 | 2021-01-08 | 2026-03-24 | |
| Comparison of Yttrium-90 Absorbed Doses Using PET/CT Versus PET/MR Imaging for Hepatic Malignancies PET/CT, PET/MR, SIRT with Y-90 - Hepatic Malignancies | Not applicable | Completed | Case Comprehensive Cancer Center | 11 | 2020-03-03 | 2022-06-22 |
| TILA-TACE in Treatment of Hepatocellular Carcinoma TILA-TACE treatment - Tumor Response Rate, Overall Survival | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2000 | 2017-11-01 | 2019-04-10 |
| Transarterial Radioembolisation in Comparison to Transarterial Chemoembolisation in Uveal Melanoma Liver Metastasis SIRT, DSM-TACE - Uveal Melanoma | Phase 2 | Completed | Charite University, Berlin, Germany | 108 | 2016-01-01 | 2025-01-24 |
| Pasireotide, Everolimus and Selective Internal Radioembolization Therapy for Unresectable Hepatic Metastases Pasireotide, Sir-sphere Radioembolization, Everolimus - Neuroendocrine Tumors | Phase 1 | Completed | Emory University | 13 | 2011-12-01 | 2018-10-18 |
| Selective Internal Radiotherapy (SIRT) Versus Transarterial Chemoembolisation (TACE) for the Treatment of Cholangiocellular Carcinoma (CCC). DEB TACE, SIRT - Intrahepatic Cholangiocellular Carcinoma | Phase 2 | Unknown | Johannes Gutenberg University Mainz | 24 | 2011-02-01 | 2017-05-23 |
| Sorafenib and Micro-therapy Guided by Primovist Enhanced MRI in Patients With Inoperable Liver Cancer RFA, Radioembolization (SIRT) - Hepatocellular Carcinoma | Phase 2 | Completed | University of Magdeburg | 529 | 2010-12-01 | 2019-05-31 |
| Selective Internal Radiation Therapy (SIRT) Versus Transarterial Chemoembolisation (TACE) for the Treatment of Hepatocellular Carcinoma (HCC). DEB TACE, SIRT - Hepatocellular Carcinoma | Phase 4 | Completed | Johannes Gutenberg University Mainz | 24 | 2010-02-01 | 2015-10-20 |
| Study of Capecitabine in Combination With SIR-Spheres in Patients With Advanced Cancer SIRT, capecitabine - Metastatic Liver Cancer | Phase 1 | Completed | Fox Chase Cancer Center | 34 | 2006-04-01 | 2015-09-07 |
Carcinoma, Hepatocellular (8) · Liver Neoplasms (2) · Cholangiocarcinoma (1) · Neuroendocrine Tumors (1) · Uveal Melanoma (1)
Second Affiliated Hospital of Guangzhou Medical University (5) · Zhongda Hospital (3) · Johannes Gutenberg University Mainz (2) · Case Comprehensive Cancer Center (1) · Charite University, Berlin, Germany (1) · Emory University (1) · Fox Chase Cancer Center (1) · Methodist Health System (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · University of Magdeburg (1)
China (9) · United States (4) · Germany (3)
Gao-Jun Teng (2) · Bassel El-Rayes, MD (1) · Gao-Jun Teng, MD (1) · Jens Ricke, Prof. Dr. (1) · Mingyue Cai, Dr. (1) · Parvez Mantry, MD (1) · Peter Malfertheiner, Prof. Dr. (1) · Ram Gurajala, MD (1) · Steven J. Cohen, M.D. (1) · Ulrich Keilholz, Prof. Dr. med. (1)
PMID 25095718, PMID 29451701, PMID 34454995, PMID 36968218, PMID 41822100