2 completed, 1 active not recruiting, 1 terminated. 4 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 2, Active not recruiting 1, Terminated 1 |
| Phase 2 | 1 | Terminated 1 |
Follow siponimod: new trials by email Literature Review of siponimod trials Research Report on siponimod
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Assess the Efficacy of Mayzent on Microglia in Secondary Progressive Multiple Sclerosis Mayzent, Ocrevus - Secondary-progressive Multiple Sclerosis | Phase 2 / Phase 3 | Terminated | State University of New York at Buffalo | 8 | 2021-11-13 | 2025-05-13 |
| Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis Fingolimod, Ofatumumab, Siponimod - Multiple Sclerosis (MS) | Phase 3 | Active not recruiting | Novartis Pharmaceuticals | 129 | 2021-10-05 | 2026-05-14 |
| Safety and Tolerability of Conversion From Oral, Injectable, or Infusion Disease Modifying Therapies to Dose-titrated Oral Siponimod (Mayzent) in Advancing RMS Patients Siponimod - Multiple Sclerosis, Relapsing Multiple Sclerosis | Phase 3 | Completed | Novartis Pharmaceuticals | 185 | 2019-02-14 | 2024-06-20 |
| Exploring the Efficacy and Safety of Siponimod in Patients With Secondary Progressive Multiple Sclerosis (EXPAND) BAF312, Placebo - Secondary Progressive Multiple Sclerosis | Phase 3 | Completed | Novartis Pharmaceuticals | 1651 | 2012-12-20 | 2024-06-05 |
Multiple Sclerosis (2) · Multiple Sclerosis, Chronic Progressive (2) · Recurrence (1)
Novartis Pharmaceuticals (3) · State University of New York at Buffalo (1)
United States (4) · Argentina (2) · Australia (2) · Austria (2) · Belgium (2) · Canada (2) · Estonia (2) · France (2) · Germany (2) · Israel (2) · Italy (2) · Latvia (2) · Poland (2) · Portugal (2) · Slovakia (2)
PMID 29576505, PMID 33328324, PMID 33791945, PMID 35261318, PMID 35379762, PMID 35380078, PMID 35639197, PMID 40248858