6 completed, 1 available, 1 no longer available, 1 recruiting. 3 Phase 2, 2 Phase 1, 2 Phase 3, 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 2 |
Follow Plasminogen: new trials by email Literature Review of Plasminogen trials Research Report on Plasminogen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial Tocilizumab, Baricitinib, Anakinra - Sepsis | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 2000 | 2026-07-09 | 2026-10-20 |
| Phase I RVC With Ocriplasmin for CRVO Ocriplasmin intravenously - Central Retinal Vein Occlusion | Phase 1 | Completed | Universitaire Ziekenhuizen KU Leuven | 4 | 2016-12-01 | 2018-01-08 |
| A Study of Prometic Plasminogen IV Infusion in Subjects With Hypoplasminogenemia Plasminogen (Human) intravenous - Hypoplasminogenemia, Congenital Plasminogen Deficiency | Phase 2 / Phase 3 | Completed | Prometic Biotherapeutics, Inc. | 15 | 2016-05-04 | 2021-08-02 |
| Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion Ocriplasmin 0.125 mg in a 0.1 mL volume - Vitreomacular Traction, Vitreomacular Adhesion | Phase 4 | Completed | Alcon Research | 62 | 2015-05-26 | 2018-08-21 |
| A Phase 1 Study of ProMetic Plasminogen (Human) Intravenous in Adults and Children With Plasminogen Deficiency Plasminogen (Human) Intravenous - Type I Plasminogen Deficiency, Hypoplasminogenemia | Phase 1 | Completed | Prometic Biotherapeutics, Inc. | 7 | 2014-12-01 | 2017-08-29 |
| Assessment of Patients Treated With JETREA® for Vitreomacular Traction Ocriplasmin - Vitreomacular Traction, Vitreomacular Adhesion | Phase 4 | Completed | Alcon Research | 628 | 2014-04-01 | 2016-10-12 |
| Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients Human Plasminogen - Ligneous Conjunctivitis | Phase 2 / Phase 3 | Completed | Kedrion S.p.A. | 12 | 2013-05-22 | 2023-01-25 |
| Sponsor Initiated Expanded Access Protocol, Intermediate-Size Patient Population Plasminogen - Ligneous Conjunctivitis | Available | Kedrion S.p.A. | 2023-10-05 | |||
| A Single-patient Study of Repeat-dose Administration of Prometic Plasminogen (Human) Intravenous Plasminogen (Human) - Hypoplasminogenemia | No longer available | Prometic Biotherapeutics, Inc. | 2020-04-24 |
Congenital Plasminogen Deficiency (4) · Plasminogen Deficiency, Type I (3) · Retinal Vein Occlusion (1) · Sepsis (1)
Prometic Biotherapeutics, Inc. (3) · Alcon Research (2) · Kedrion S.p.A. (2) · Assistance Publique - Hôpitaux de Paris (1) · Universitaire Ziekenhuizen KU Leuven (1)
United States (3) · Australia (1) · Belgium (1) · France (1) · Italy (1) · Norway (1)
Amy Shapiro, MD (1) · Peter Stalmans, MD PhD (1)