3 completed, 2 no longer available, 1 recruiting, 1 unknown. 2 Phase 2, 2 Phase 3, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
| Not applicable | 1 | Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Congenital Plasminogen Deficiency: new trials by email Literature Review of Congenital Plasminogen Deficiency trials Research Report on Congenital Plasminogen Deficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Treatment of Ligneous Conjunctivitis in Children With Plasminogen Deficiency Aliquoted allogeneic donor plasma in patient's conjunctiva - Plasminogen Deficiency | Not applicable | Unknown | University of Saskatchewan | 1 | 2022-12-15 | 2023-12-15 |
| Study of Individuals Affected With Hypoplasminogenemia Plasminogen Deficiency | Recruiting | Indiana Hemophilia &Thrombosis Center, Inc. | 100 | 2018-12-18 | 2026-06-04 | |
| A Study of Prometic Plasminogen IV Infusion in Subjects With Hypoplasminogenemia Plasminogen (Human) intravenous - Hypoplasminogenemia, Congenital Plasminogen Deficiency | Phase 2 / Phase 3 | Completed | Prometic Biotherapeutics, Inc. | 15 | 2016-05-04 | 2021-08-02 |
| A Phase 1 Study of ProMetic Plasminogen (Human) Intravenous in Adults and Children With Plasminogen Deficiency Plasminogen (Human) Intravenous - Type I Plasminogen Deficiency, Hypoplasminogenemia | Phase 1 | Completed | Prometic Biotherapeutics, Inc. | 7 | 2014-12-01 | 2017-08-29 |
| Efficacy/Safety of Human Plasminogen Eye Drop in Ligneous Conjunctivitis Patients Human Plasminogen - Ligneous Conjunctivitis | Phase 2 / Phase 3 | Completed | Kedrion S.p.A. | 12 | 2013-05-22 | 2023-01-25 |
| A Treatment Protocol for Expanded Access Administration of Prometic Plasminogen Due to Closure of Clinical Trial Ryplazim - Hypoplasminogenemia | No longer available | Prometic Biotherapeutics, Inc. | 2022-12-09 | |||
| A Single-patient Study of Repeat-dose Administration of Prometic Plasminogen (Human) Intravenous Plasminogen (Human) - Hypoplasminogenemia | No longer available | Prometic Biotherapeutics, Inc. | 2020-04-24 |
Plasminogen Deficiency, Type I (2)
Plasminogen (4)
Prometic Biotherapeutics, Inc. (4) · Indiana Hemophilia &Thrombosis Center, Inc. (1) · Kedrion S.p.A. (1) · University of Saskatchewan (1)
United States (5) · Canada (2) · Italy (2) · Argentina (1) · Australia (1) · Austria (1) · Greece (1) · Israel (1) · Norway (1) · Thailand (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Amy D Shapiro, MD (1) · Amy Shapiro, MD (1) · Flora Peyvandi, MD, PhD (1) · Heather McDaniel, MD (1) · Jeremy Lorber, MD (1)
PMID 42528055, PMID 1455395, PMID 17900274, PMID 25208887, PMID 27629020, PMID 29321155, PMID 35346720, PMID 37674358, PMID 40403316, PMID 42226455