8 completed, 2 terminated. 4 Phase 1, 3 Phase 3, 1 Not applicable, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 4 |
| Phase 3 | 3 | Terminated 2, Completed 1 |
| Not applicable | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Placebo vaginal ring: new trials by email Literature Review of Placebo vaginal ring trials Research Report on Placebo vaginal ring
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Estrogen and the Urogenital Microbiome in GSM Estradiol vaginal ring, Placebo vaginal ring - Menopause | Phase 4 | Completed | Oregon Health and Science University | 40 | 2018-02-01 | 2019-11-22 |
| Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in Women With Primary Dysmenorrhea (With Optional Extension) (MK-8342B-059) Etonogestrel (ENG) 125 μg + 17β-estradiol (E2) 300 μg vaginal ring, Placebo vaginal ring, Ibuprofen - Moderate to Severe Primary Dysmenorrhea | Phase 3 | Terminated | Organon and Co | 25 | 2016-02-11 | 2024-05-28 |
| Efficacy and Safety of Etonogestrel + 17β-Estradiol Vaginal Ring (MK-8342B) in the Treatment of Women With Primary Dysmenorrhea (MK-8342B-060) ENG 125 μg + E2 300 μg vaginal ring (MK-8342B), Placebo vaginal ring, Ibuprofen - Dysmenorrhea | Phase 3 | Terminated | Organon and Co | 18 | 2016-02-09 | 2024-05-28 |
| Performance and Safety of Vaginal Ring Applicator in Healthy Females (MK-8342A-063) Placebo vaginal ring, Single-use, non-sterile applicator - Contraception: Optional Applicator for Insertion of Vaginal Ring | Phase 3 | Completed | Organon and Co | 164 | 2014-12-11 | 2024-05-17 |
| Safety and Pharmacokinetics of Dapivirine Vaginal Ring in Post-menopausal Women Dapivirine Vaginal Ring, Placebo Vaginal Ring - Human Immunodeficiency Virus | Phase 2 | Completed | International Partnership for Microbicides, Inc. | 96 | 2013-12-01 | 2022-11-03 |
| Functionality of Male Condoms With a Silicone Elastomer Vaginal RIng Placebo Vaginal Ring, Condom - Human Immunodeficiency Virus | Phase 1 | Completed | International Partnership for Microbicides, Inc. | 70 | 2013-02-01 | 2018-03-29 |
| Safety and Efficacy Trial of a Dapivirine Vaginal Matrix Ring in Healthy HIV-Negative Women Placebo Vaginal Ring, Dapivirine Vaginal Ring, 25 mg - HIV Infections | Not applicable | Completed | International Partnership for Microbicides, Inc. | 1959 | 2012-03-27 | 2022-10-19 |
| Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring Dapivirine Vaginal Ring, Maraviroc Vaginal Ring, Placebo Vaginal Ring - HIV Infections | Phase 1 | Completed | International Partnership for Microbicides, Inc. | 48 | 2011-11-01 | 2015-09-10 |
| Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring Dapivirine Vaginal Ring, Placebo vaginal ring - HIV Infections | Phase 1 | Completed | International Partnership for Microbicides, Inc. | 16 | 2009-08-01 | 2017-09-08 |
| Feasibility Study of a Vaginal Ring for Delivery of TMC120 (Dapivirine) placebo vaginal ring, TMC120 (dapivirine) vaginal ring - HIV Infections | Phase 1 | Completed | International Partnership for Microbicides, Inc. | 12 | 2004-10-01 | 2009-09-01 |
HIV Infections (4) · Acquired Immunodeficiency Syndrome (2) · Dysmenorrhea (1)
International Partnership for Microbicides, Inc. (6) · Organon and Co (3) · Oregon Health and Science University (1)
United States (4) · Belgium (2) · South Africa (1) · Uganda (1)
Annalene Nel (1) · Annalene Nel, PhD (1) · Beatrice A Chen, MD, MPH (1) · Dr Luc Van Bortel (1) · Jennifer Lillemon (1) · Lori Panther, MD, MPH (1) · Ron Frezieres (1)
PMID 27207028, PMID 27959766, PMID 29855975, PMID 30289485, PMID 33542153, PMID 35289688, PMID 35420551, PMID 36345569, PMID 38589266, PMID 42277878
2015 (2), 5UM1AI068633-07 (1)