olipudase alfa: Clinical Trials

4 completed. 4 Phase 2, 1 Phase 1, 1 Phase 3.

By phase and status

Phase	Trials	Status
Phase 2	4	Completed 4
Phase 1	1	Completed 1
Phase 3	1	Completed 1

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Trials (filtered) newest first · largest first

All 4 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
A Study to Evaluate Safety and Tolerability of Olipudase Alfa in Pediatric and Adult Participants With Acid Sphingomyelinase Deficiency (ASMD) Who Completed the DFI12712 or the LTS13632 Study in France Olipudase alfa - Acid Sphingomyelinase Deficiency	Phase 2	Completed	Sanofi	3	2021-11-18	2026-04-13
Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency placebo (saline), Olipudase alfa - Sphingomyelin Lipidosis	Phase 2 / Phase 3	Completed	Genzyme, a Sanofi Company	36	2015-12-18	2024-11-07
Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18 Years of Age With Acid Sphingomyelinase Deficiency Olipudase alfa - Sphingomyelin Lipidosis	Phase 1 / Phase 2	Completed	Genzyme, a Sanofi Company	20	2015-05-01	2022-03-23
A Long-Term Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency GZ402665 - Sphingomyelin Lipidosis	Phase 2	Completed	Genzyme, a Sanofi Company	25	2013-12-04	2024-07-03

Conditions studied

Niemann-Pick Disease, Type A (3)  ·  Niemann-Pick Diseases (1)

Sponsors

Genzyme, a Sanofi Company (3)  ·  Sanofi (1)

Countries

France (4)  ·  Brazil (3)  ·  Germany (3)  ·  Italy (3)  ·  United Kingdom (3)  ·  United States (3)  ·  Belgium (2)  ·  Argentina (1)  ·  Australia (1)  ·  Bulgaria (1)  ·  Chile (1)  ·  Japan (1)  ·  Netherlands (1)  ·  Portugal (1)  ·  Spain (1)

Results publications

PMID 29305734, PMID 32620536, PMID 33875845, PMID 37098529, PMID 38042851, PMID 39774103, PMID 40937531

NIH funding

2015 (1)