5 completed, 1 active not recruiting, 1 not yet recruiting. 5 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Active not recruiting 1, Not yet recruiting 1 |
| Phase 1 | 4 | Completed 3, Active not recruiting 1 |
Follow NOX-A12: new trials by email Literature Review of NOX-A12 trials Research Report on NOX-A12
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Olaptesed With Pembrolizumab and Nanoliposomal Irinotecan or Gemcitabine/Nab-Paclitaxel in MSS Pancreatic Cancer Olaptesed pegol, Pembrolizumab - Metastatic Pancreatic Cancer | Phase 2 | Not yet recruiting | TME Pharma AG | 60 | 2026-01-01 | 2025-06-27 |
| Glioblastoma Treatment With Irradiation and Olaptesed Pegol (NOX-A12) in MGMT Unmethylated Patients Olaptesed pegol, Radiotherapy, Bevacizumab - Glioblastoma | Phase 1 / Phase 2 | Active not recruiting | TME Pharma AG | 117 | 2019-09-12 | 2025-06-25 |
| Olaptesed (NOX-A12) Alone and in Combination With Pembrolizumab in Colorectal and Pancreatic Cancer Olaptesed pegol - Monotherapy, Olaptesed pegol + Pembrolizumab - Combination Therapy - Metastatic Colorectal Cancer, Metastatic Pancreatic Cancer | Phase 1 / Phase 2 | Completed | TME Pharma AG | 20 | 2017-04-18 | 2020-07-08 |
| NOX-A12 in Combination With Bendamustine and Rituximab in Relapsed Chronic Lymphocytic Leukemia (CLL) NOX-A12 - Chronic Lymphocytic Leukemia | Phase 2 | Completed | TME Pharma AG | 28 | 2012-03-01 | 2017-05-22 |
| NOX-A12 in Combination With Bortezomib and Dexamethasone in Relapsed Multiple Myeloma NOX-A12 - Multiple Myeloma | Phase 2 | Completed | TME Pharma AG | 28 | 2012-03-01 | 2015-10-06 |
| NOX-A12 Multiple Ascending Dose Study in Healthy Volunteers NOX-A12, Filgrastim, NOX-A12 in combination with Filgrastim - Hematopoietic Stem Cell Transplantation | Phase 1 | Completed | TME Pharma AG | 12 | 2010-08-01 | 2014-06-26 |
| NOX-A12 First-in-human (FIH) Study NOX-A12 - Autologous Stem Cell Transplantation | Phase 1 | Completed | TME Pharma AG | 48 | 2009-10-01 | 2014-06-26 |
Pancreatic Neoplasms (2) · Brain Neoplasms (1) · Colorectal Neoplasms (1) · Glioblastoma (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Multiple Myeloma (1)
TME Pharma AG (7)
Germany (5) · Austria (2) · France (2) · Italy (2) · Belgium (1)
Kai Riecke, MD (2) · Frank Fliegert, MD (1) · Stefan Zeitler, MD (1)
2016 (1), 2018 (1)