1 active not recruiting, 1 completed, 1 no longer available, 1 terminated. 2 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 2 | 2 | Active not recruiting 1, Withdrawn 1 |
Follow Neoantigen DNA vaccine: new trials by email Literature Review of Neoantigen DNA vaccine trials Research Report on Neoantigen DNA vaccine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalized Neoantigen Vaccine in Combination With Durvalumab (MEDI4736) in Extensive Stage Small Cell Lung Cancer Neoantigen DNA vaccine, Durvalumab, TDS-IM v2.0 Device - Extensive-stage Small Cell Lung Cancer | Phase 2 | Active not recruiting | Washington University School of Medicine | 6 | 2022-03-30 | 2025-10-22 |
| PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma Durvalumab, Tremelimumab, TDS-IM v1.0 System - Renal Cell Carcinoma | Phase 2 | Withdrawn | Washington University School of Medicine | 2020-08-31 | 2020-08-13 | |
| Neoantigen DNA Vaccine Alone vs. Neoantigen DNA Vaccine Plus Durvalumab in Triple Negative Breast Cancer Patients Following Standard of Care Therapy Durvalumab, Neoantigen DNA vaccine, TDS-IM system (Inchor Medical Systems) - Triple Negative Breast Cancer, Triple Negative Breast Neoplasms | Phase 1 | Terminated | Washington University School of Medicine | 18 | 2019-07-23 | 2024-05-28 |
| Neoantigen DNA Vaccine in Combination With Nivolumab/Ipilimumab and PROSTVAC in Metastatic Hormone-Sensitive Prostate Cancer PROSTVAC-V, PROSTVAC-F, Nivolumab - Metastatic Hormone-Sensitive Prostate Cancer | Phase 1 | Completed | Washington University School of Medicine | 19 | 2018-09-14 | 2022-08-05 |
| Expanded Access Neoantigen Vaccine in Solid Tumors Neoantigen DNA Vaccine, Integrated electroporation device - Solid Tumor, Adult | No longer available | Washington University School of Medicine | 2024-03-12 |
Carcinoma, Renal Cell (1) · Small Cell Lung Carcinoma (1) · Triple Negative Breast Neoplasms (1)
Washington University School of Medicine (5)
United States (4)
James J Hsieh, M.D., Ph.D. (1) · Jeffrey Ward, M.D., Ph.D. (1) · Russell Pachynski, M.D. (1) · William E Gillanders, M.D. (1) · William Gillanders, M.D. (1)
R01CA240983 (1)