3 completed, 1 active not recruiting, 1 recruiting. 3 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Active not recruiting 1, Completed 1, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
Follow N-acetylmannosamine: new trials by email Literature Review of N-acetylmannosamine trials Research Report on N-acetylmannosamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| An Open-Label Phase 2 Study of N-Acetyl-D-Mannosamine (ManNAc) in Subjects With Podocyte Diseases ManNAc - Focal Segmental Glomerulosclerosis, Minimal Change Disease | Phase 2 | Recruiting | National Human Genome Research Institute (NHGRI) | 30 | 2026-10-27 | 2026-10-30 |
| Multi-Center Study of ManNAc for GNE Myopathy ManNAc, Placebo - GNE Myopathy | Phase 2 | Active not recruiting | Leadiant Biosciences, Inc. | 54 | 2022-04-05 | 2025-06-13 |
| A Phase 1 Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ManNAc in Subjects With Primary Podocyte Diseases N-acetyl D-mannosamine - Kidney Disease | Phase 1 | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 10 | 2016-07-07 | 2023-02-24 |
| An Open Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy ManNAc - GNE Myopathy | Phase 2 | Completed | National Human Genome Research Institute (NHGRI) | 12 | 2015-02-05 | 2019-04-16 |
| Phase I Clinical Trial of ManNAc in Patients With GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM) ManNAc - Hereditary Inclusion Body Myopathy (HIBM), GNE Myopathy | Phase 1 | Completed | National Human Genome Research Institute (NHGRI) | 26 | 2012-09-11 | 2017-10-19 |
Distal myopathy, Nonaka type (3) · Kidney Diseases (2) · Proteinuria (2) · Glomerulonephritis, Membranous (1) · Glomerulosclerosis, Focal Segmental (1) · Macular dystrophy, corneal type 1 (1) · Nephrosis, Lipoid (1) · Nephrotic Syndrome (1)
National Human Genome Research Institute (NHGRI) (3) · Leadiant Biosciences, Inc. (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1)
United States (5)
Anthony A. Amato, MD (1) · Francis Rossignol, MD (1) · Jeffrey B Kopp, M.D. (1) · Nuria Carrillo, M.D. (1) · Nuria Carrillo-Carrasco, M.D. (1) · William A Gahl, M.D. (1)
PMID 33893973, PMID 41630898, PMID 34257421
U01AR070498 (1)