4 completed, 1 terminated. 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
Follow lufotrelvir: new trials by email Literature Review of lufotrelvir trials Research Report on lufotrelvir
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Investigate the Mass Balance, Metabolism, and Excretion of [14C]-PF-07304814 in Healthy Participants PF-07304814 - Healthy | Phase 1 | Completed | Pfizer | 5 | 2021-10-07 | 2025-10-20 |
| PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial) PF-07304814, Placebo, Remdesivir - COVID-19 | Phase 3 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 58 | 2021-09-15 | 2024-02-09 |
| Single Ascending Dose Study of Intravenous Infusion of PF 07304814 in Healthy Adult Participants PF-07304814, Placebo - Healthy | Phase 1 | Completed | Pfizer | 16 | 2020-10-23 | 2021-01-06 |
| First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19. PF-07304814, Placebo - Viral Disease | Phase 1 | Completed | Pfizer | 26 | 2020-09-09 | 2023-05-03 |
| ACTIV-3: Therapeutics for Inpatients With COVID-19 LY3819253, Placebo, Remdesivir - Covid19 | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 2753 | 2020-08-04 | 2023-08-25 |
COVID-19 (4) · Virus Diseases (4) · Coronaviridae Infections (2) · Coronavirus Infections (2) · Nidovirales Infections (2) · RNA Virus Infections (2) · Severe Acute Respiratory Syndrome (2)
Pfizer (3) · National Institute of Allergy and Infectious Diseases (NIAID) (2)
United States (5) · Denmark (2) · Spain (2) · Belgium (1) · Brazil (1) · Greece (1) · Nigeria (1) · Poland (1) · Singapore (1) · Switzerland (1) · Uganda (1) · United Kingdom (1)
James Neaton, Prof. (1) · Jens Lundgren, Prof. (1) · Prof. James Neaton (1) · Prof. Jens Lundgren (1)
PMID 33356051, PMID 34473343, PMID 34541899, PMID 34928698, PMID 34953520, PMID 35298440, PMID 35713300, PMID 35817072, PMID 35939810, PMID 36285536, PMID 37559753, PMID 37948759, PMID 39922466, PMID 40262279