5 completed. 3 Phase 2, 2 Phase 3.
By phase and status
Follow ISIS 3521: new trials by email Literature Review of ISIS 3521 trials Research Report on ISIS 3521
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|
A Phase 2 Trial of Antisense Nucleotide to PKC-Alpha (LY900003, ISIS 3521) Plus Gemcitabine and Carboplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer.
Gemcitabine, Carboplatin, LY900003 - Carcinoma, Non-Small-Cell Lung, Pulmonary Neoplasms | Phase 2 | Completed | Eli Lilly and Company | | 2002-06-01 | 2006-07-19 |
A Phase 3 Trial of LY900003 Plus Gemcitabine and Cisplatin Versus Gemcitabine and Cisplatin in Patients With Advanced, Previously Untreated Non-Small Cell Lung Cancer
LY900003 - Carcinoma, Non-Small-Cell Lung | Phase 3 | Completed | Eli Lilly and Company | | 2002-03-01 | 2006-07-19 |
Carboplatin and Paclitaxel With or Without ISIS 3521 in Treating Patients With Non-Small Cell Lung Cancer
ISIS 3521, carboplatin, paclitaxel - Lung Cancer | Phase 3 | Completed | Ionis Pharmaceuticals, Inc. | | 2000-10-13 | 2022-12-05 |
Chemotherapy in Treating Women With Previously Treated Metastatic Breast Cancer
ISIS 3521, ISIS 5132 - Breast Cancer | Phase 2 | Completed | Eastern Cooperative Oncology Group | | 1998-07-13 | 2023-06-18 |
ISIS 3521 in Treating Patients With Advanced, Unresectable, or Metastatic Non-small Cell Lung Cancer or Unresectable or Metastatic Melanoma
ISIS 3521 - Lung Cancer, Melanoma (Skin) | Phase 2 | Completed | European Organisation for Research and Treatment of Cancer - EORTC | 50 | 1998-06-01 | 2012-07-11 |
Conditions studied
Carcinoma, Non-Small-Cell Lung (4) · Lung Neoplasms (3) · Adenocarcinoma (1) · Breast Neoplasms (1) · Carcinoma, Squamous Cell (1) · Melanoma (1)
Sponsors
Eli Lilly and Company (2) · Eastern Cooperative Oncology Group (1) · European Organisation for Research and Treatment of Cancer - EORTC (1) · Ionis Pharmaceuticals, Inc. (1)
Countries
United States (4) · Belgium (2) · France (2) · Germany (2) · Netherlands (2) · Norway (2) · Switzerland (2) · United Kingdom (2) · Argentina (1) · Austria (1) · Chile (1) · Denmark (1) · Hungary (1) · India (1) · Italy (1)
Top investigators
Jon Holmlund, MD (1) · Shoshana Kaplan, MD (1) · William J. Gradishar, MD (1)