6 recruiting, 5 completed, 5 not yet recruiting, 1 terminated. 5 Phase 3, 4 Not applicable, 1 Early Phase 1, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Not yet recruiting 3, Completed 1, Recruiting 1 |
| Not applicable | 4 | Recruiting 2, Completed 1, Unknown 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
| Phase 1 | 1 | Recruiting 1 |
| Phase 2 | 1 | Terminated 1 |
Follow Intravenous Thrombolysis: new trials by email Literature Review of Intravenous Thrombolysis trials Research Report on Intravenous Thrombolysis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre - Stroke, Acute Ischemic, Medium Vessel Occlusion | Phase 3 | Not yet recruiting | University of Calgary | 800 | 2026-12-15 | 2026-10-30 |
| Extended Time Window Intravenous Thrombolysis Registry for Acute Ischemic Stroke Intravenous Thrombolysis - Stroke, Acute Ischemic Stroke | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 3000 | 2026-04-01 | 2026-04-17 | |
| Intravenous Thrombolysis in Acute Ischemic Stroke with Active Cancer Intravenous thrombolysis - Stroke, Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 280 | 2025-03-01 | 2025-02-24 |
| Intravenous Thrombosis and Patients with Prior Ischemic Stroke Within 3 Months Intravenous Thrombolysis - Stroke, Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 306 | 2025-03-01 | 2025-02-24 |
| Intravenous Thrombolysis and NOAC Intravenous thrombolysis - Acute Ischemic Stroke | Phase 3 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 280 | 2025-01-27 | 2025-02-24 |
| Intra-arterial Hypothermic Magnesium Sulfate Infusion in Combination with Endovascular Thrombectomy in Acute Ischemic Stroke Intra-arterial hypothermic magnesium sulfate infusion, Endovascular thrombectomy, Intravenous thrombolysis - Acute Ischemic Stroke | Early Phase 1 | Not yet recruiting | Capital Medical University | 6 | 2025-01-10 | 2025-01-07 |
| Study on Hibernation-like Therapy Based on Mechanical Thrombectomy chlorpromazine and promethazine, Placebo group, endovascular thrombectomy - Acute Ischemic Stroke | Phase 1 | Recruiting | Capital Medical University | 32 | 2024-11-09 | 2024-12-20 |
| Extending the Time Window for Intravenous Tenecteplase in Patients With Distal Medium Vessel Occlusions Stroke Intravenous thrombolysis, Standard medical management - Acute Ischemic Stroke | Not applicable | Recruiting | The First Affiliated Hospital of University of Science and Technology of China | 560 | 2024-10-02 | 2024-10-24 |
| Registration of Intravenous Thrombolysis for Acute Ischemic Stroke in Southwestern China（IVTIS） intravenous thrombolysis - Stroke, Acute | Recruiting | Zhengzhou Yuan | 3000 | 2023-11-20 | 2023-11-28 | |
| Safety and Efficacy of Levofloxacin Combined With Intravenous Thrombolysis for Acute Ischemic Stroke Levofloxacin, Levofloxacin simulant - Acute Ischemic Stroke | Not applicable | Recruiting | Yi Yang | 100 | 2023-06-01 | 2024-10-02 |
| Endovascular Thrombectomy Alone Versus Intravenous Thrombolysis Plus Thrombectomy on Acute Basilar Artery Occlusion Intravenous thrombolysis, Endovascular thrombectomy - Basilar Artery Occlusion, Acute Cerebrovascular Accident | Phase 3 | Completed | The First Affiliated Hospital of University of Science and Technology of China | 338 | 2023-05-09 | 2026-08-12 |
| Mechanical Thrombectomy With the FlowTriever Device in Acute Pulmonary Embolism - a Retrospective Analysis Mechanical thrombectomy, Intravenous thrombolysis - Pulmonary Embolism | Completed | Kristina Svennerholm | 132 | 2023-04-01 | 2025-05-20 | |
| a Cohort Study of Ischemic Cerebrovascular Disease Intravenous thrombolysis - Ischaemic Stroke | Recruiting | Xiangya Hospital of Central South University | 5000 | 2022-11-01 | 2023-06-28 | |
| Thrombolysis in STEMI Patients Compared With pPCI on Recanalization Time in the Context of the COVID-19 Outbreak. Thrombolytic, percutaneous coronary stenting - STEMI - ST Elevation Myocardial Infarction | Not applicable | Unknown | Ya-Wei Xu | 120 | 2022-04-01 | 2022-05-26 |
| Direct Intra-arterial Thrombectomy in Order to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals intra-arterial thrombectomy, Intravenous thrombolysis - Ischemic Stroke, Large Vessel Occlusion | Not applicable | Completed | Changhai Hospital | 656 | 2018-02-21 | 2019-10-29 |
| Cerebral Haemodynamics in Stroke Thrombolysis Study (CHIST) intravenous thrombolysis - Ischaemic Stroke | Completed | University of Leicester | 22 | 2016-04-01 | 2020-01-30 | |
| Feasibility Study of IV Recombinant Tissue Plasminogen Activator (rtPA) vs. Primary Endovascular Therapy for Acute Ischemic Stroke Intravenous Thrombolysis, Endovascular Arterial Reperfusion - Stroke, Ischemic Stroke | Phase 2 | Terminated | Mayo Clinic | 1 | 2013-01-01 | 2016-10-05 |
| Swiss Intravenous and Intra-arterial Thrombolysis for Treatment of Acute Ischemic Stroke Registry Intravenous Thrombolysis, Intraarterial Thrombolysis - Ischemic Stroke | Completed | Insel Gruppe AG, University Hospital Bern | 1476 | 2007-12-01 | 2016-04-13 |
Ischemic Stroke (14) · Stroke (6) · Pulmonary Embolism (1) · ST Elevation Myocardial Infarction (1) · Thrombosis (1)
Second Affiliated Hospital, Zhejiang University, School of Medicine (3) · Capital Medical University (2) · The First Affiliated Hospital of University of Science and Technology of China (2) · Changhai Hospital (1) · Insel Gruppe AG, University Hospital Bern (1) · Kristina Svennerholm (1) · Mayo Clinic (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · University of Calgary (1) · University of Leicester (1) · Xiangya Hospital of Central South University (1) · Ya-Wei Xu (1) · Yi Yang (1) · Zhengzhou Yuan (1)
China (11) · Canada (1) · Sweden (1) · Switzerland (1) · United Kingdom (1) · United States (1)
Min Lou, PhD, MD (2) · Benqiang Deng, M.D. (1) · Bijoy K Menon, MD (1) · Charles Majoie, M.D. (1) · Craig Anderson, MD (1) · Jianmin Liu, M.D. (1) · Kevin M Barrett, MD (1) · Krassen Nedeltechev, MD Prof. (1) · Kristina Svennerholm, MD, PhD (1) · Marcel Arnold, MD Prof. (1) · Thompson G Robinson, MD FRCP (1) · Wei Hu, MD (1) · Xunming Ji, Doctor (1) · Yamei Tang (1) · Yawei Xu, Doctor (1)
PMID 32374959, PMID 33496186, PMID 34872341, PMID 34915738, PMID 35017204, PMID 35222248, PMID 35232782, PMID 35240861, PMID 35688618, PMID 36151441, PMID 36172030, PMID 36504640, PMID 37430361, PMID 40031887, PMID 40152857, PMID 41955857, PMID 41974576, PMID 42586736