3 completed, 2 terminated, 1 recruiting. 6 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 3, Terminated 2, Recruiting 1 |
| Phase 2 | 1 | Completed 1 |
Follow Iduronidase: new trials by email Literature Review of Iduronidase trials Research Report on Iduronidase
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PEARL (PrEnAtal Enzyme Replacement Therapy for Lysosomal Storage Disorders) Aldurazyme (laronidase) - MPS I, MPS II | Phase 1 | Recruiting | University of California, San Francisco | 10 | 2021-07-01 | 2026-03-17 |
| Administration of IV Laronidase Post Bone Marrow Transplant in Hurler Laronidase - Hurler Syndrome | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 11 | 2012-05-29 | 2020-03-20 |
| Immune Tolerance Study With Aldurazyme® (Laronidase) Laronidase, Cyclosporine A (CsA), Azathioprine (Aza) - Mucopolysaccharidosis I | Phase 1 / Phase 2 | Completed | Genzyme, a Sanofi Company | 7 | 2008-09-01 | 2014-07-02 |
| Intrathecal Enzyme Replacement for Hurler Syndrome IRT Laronidase - Hurler Syndrome | Phase 1 | Completed | Masonic Cancer Center, University of Minnesota | 26 | 2008-01-02 | 2018-12-03 |
| Extension Study of Intrathecal Enzyme Replacement Therapy for MPS I laronidase - Spinal Cord Compression, Mucopolysaccharidosis I | Phase 1 | Terminated | Patricia I. Dickson, M.D. | 3 | 2008-01-01 | 2013-02-21 |
| Intrathecal Enzyme Replacement Therapy for Spinal Cord Compression in Mucopolysaccharidosis (MPS) I laronidase - Mucopolysaccharidosis I, Lysosomal Storage Diseases | Phase 1 | Terminated | Patricia I. Dickson, M.D. | 4 | 2005-11-01 | 2013-02-21 |
Mucopolysaccharidosis I (5) · Mucopolysaccharidoses (3) · Lysosomal Storage Diseases (2) · Spinal Cord Compression (2) · Gaucher Disease (1) · Mucopolysaccharidosis IV (1) · Mucopolysaccharidosis VI (1) · Mucopolysaccharidosis VII (1) · Sudden Infant Death (1) · Wolman Disease (1)
Masonic Cancer Center, University of Minnesota (2) · Patricia I. Dickson, M.D. (2) · Genzyme, a Sanofi Company (1) · University of California, San Francisco (1)
United States (5) · Finland (2) · Brazil (1) · Russia (1)
Paul Orchard, MD (2) · Patricia I Dickson, M.D. (1) · Patricia I Dickson, MD (1) · Tippi MacKenzie, MD (1)
PMID 15324318, PMID 19948615, PMID 21637107, PMID 23510062, PMID 28119821, PMID 28374935, PMID 28657663, PMID 30337566, PMID 31575939, PMID 32102934, PMID 37955580, PMID 39891377, PMID 9918480