12 completed. 5 Phase 3, 3 Phase 2, 3 Phase 4, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 5 |
| Phase 2 | 3 | Completed 3 |
| Phase 4 | 3 | Completed 3 |
| Not applicable | 1 | Completed 1 |
Follow Grazax: new trials by email Literature Review of Grazax trials Research Report on Grazax
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction Dupixent®, Grazax®, Dupixent® Placebo - Allergic Rhinoconjunctivitis, Grass Pollen Allergy | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 199 | 2020-11-05 | 2026-04-27 |
| Standardising Nasal Allergen Challenge in Adult With Hay Fever Aquagen, Grazax - Allergic Rhinitis | Not applicable | Completed | Imperial College London | 20 | 2019-09-26 | 2021-08-31 |
| Study Immunology and Safety of 60-day Treatment of SQ Grass SLIT (Sublingual Immunotherapy)-Tablet in Adult Subjects With Grass Pollen-induced Allergic Rhinoconjunctivitis Phleum pratense grass pollen allergen extract, placebo - Seasonal Allergic Rhinitis | Phase 3 | Completed | Abbott | 107 | 2014-10-01 | 2016-01-11 |
| Grass Pollen Allergen Immunotherapy Tablet (AIT) Time Course Study Grazax, Grazax Placebo - Allergic Rhinitis | Phase 2 | Completed | Imperial College London | 46 | 2013-09-01 | 2019-12-04 |
| Molecular and Cellular Mechanism in the Course of Immunotherapy With a Phleum Pratense Oral Lyophilisate Grazax, Placebo - Allergic Rhinitis Due to Grass Pollens | Phase 4 | Completed | ALK-Abelló A/S | 51 | 2013-04-01 | 2017-06-28 |
| Long-Term Effects of Sublingual Grass Therapy Sublingual immunotherapy (SLIT), Subcutaneous immunotherapy (SCIT), Placebo - Rhinitis, Allergic, Seasonal | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 106 | 2011-03-01 | 2017-06-02 |
| Grazax Asthma Prevention Grazax, Placebo - Allergic Rhinitis | Phase 3 | Completed | ALK-Abelló A/S | 812 | 2010-01-01 | 2016-09-08 |
| Molecular and Cellular Mechanism in Rhinitis Allergic Patients Treated With GRAZAX® GRAZAX - Allergic Rhinoconjunctivitis | Phase 4 | Completed | ALK-Abelló A/S | 58 | 2009-09-01 | 2018-01-17 |
| A Trial Evaluating Tolerability of Grazax Treatment in Combination With Antihistamine Grazax + Aerius, Grazax + placebo - Allergic Rhinoconjunctivitis | Phase 3 | Completed | ALK-Abelló A/S | 46 | 2008-09-01 | 2013-02-08 |
| A Phase III Trial Assessing the Pharmacodynamic Effect and the Tolerability of Grazax Treatment Grazax, placebo - Grass Pollen Allergy | Phase 3 | Completed | ALK-Abelló A/S | 276 | 2008-04-01 | 2011-08-30 |
| Tolerability of Grazax in Patients With Hayfever in Real Life Settings Grazax - Allergic Rhinoconjunctivitis | Phase 4 | Completed | ALK-Abelló A/S | 628 | 2007-11-01 | 2024-05-29 |
| A Trial of Grazax in Subjects With Hayfever Grazax - Allergy | Phase 3 | Completed | ALK-Abelló A/S | 329 | 2006-12-01 | 2015-06-24 |
Rhinitis, Allergic, Seasonal (4) · Rhinitis, Allergic (3) · Asthma (2) · Hypersensitivity (2) · Rhinitis (1)
ALK-Abelló A/S (7) · Imperial College London (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Abbott (1)
United Kingdom (4) · Spain (2) · Denmark (1) · Finland (1) · France (1) · Germany (1) · Russia (1) · United States (1)
Kim Simonsen, MD (2) · Dmitri Kazei, MD PhD (1) · Erkka Valovirta, MD (1) · Prof Stephen Durham, MD (1) · Stephen Durham, MD (1) · Stephen R Durham, Prof. (1) · Stephen R. Durham, MD (1)
PMID 21741092, PMID 22594491, PMID 23725348, PMID 24290282, PMID 26682038, PMID 28196255, PMID 37460024
2018 (1)