Exablate BBBD: Clinical Trials

3 completed, 2 active not recruiting, 1 suspended, 1 withdrawn. 4 Phase 1, 4 Phase 2, 3 Not applicable.

By phase and status

Phase	Trials	Status
Phase 1	4	Active not recruiting 2, Completed 2
Phase 2	4	Active not recruiting 2, Completed 2
Not applicable	3	Completed 1, Suspended 1, Withdrawn 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Safety and Effectiveness of Blood-Brain Barrier Disruption (BBBD) in Subjects With Suspected Infiltrating Glioma Exablate BBBD - Glioma	Not applicable	Withdrawn	InSightec		2024-10-23	2025-05-02
ExAblate Blood Brain Barrier Disruption (BBBD) for Planned Surgery in Suspected Infiltrating Glioma ExAblate 4000 - Type 2 - Glioma	Not applicable	Suspended	InSightec	15	2023-10-01	2022-08-03
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG) Exablate, Doxorubicin - Brain Tumor	Phase 1 / Phase 2	Active not recruiting	InSightec	10	2023-01-04	2026-04-17
Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG Exablate, Doxorubicin - Brain Tumor	Phase 1 / Phase 2	Active not recruiting	InSightec	10	2023-01-04	2026-04-21
Exablate Blood-Brain Barrier Disruption for the Treatment of rGBM in Subjects Undergoing Carboplatin Monotherapy Carboplatin, Exablate BBBD - Recurrent Glioblastoma	Phase 1 / Phase 2	Completed	InSightec	28	2020-11-06	2026-03-20
Exablate Blood-Brain Barrier Disruption With Carboplatin for the Treatment of rGBM Exablate BBBD, Carboplatin - Recurrent Glioblastoma	Phase 1 / Phase 2	Completed	InSightec	13	2020-10-13	2026-01-20
Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases ExAblate BBBD - Breast Cancer, Brain Metastases	Not applicable	Completed	InSightec	8	2019-09-18	2026-03-20

Conditions studied

Brain Neoplasms (3)  ·  Glioblastoma (3)  ·  Glioma (2)  ·  Breast Neoplasms (1)

Sponsors

InSightec (7)

Countries

United States (4)  ·  Canada (3)  ·  Italy (1)  ·  South Korea (1)

Top investigators

Graeme Woodworth, MD (2)  ·  Nir Lipsman, MD (1)

Results publications

PMID 34504017