danoprevir: Clinical Trials

20 completed. 20 Phase 1.

By phase and status

Phase	Trials	Status
Phase 1	20	Completed 20

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All 20 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Pharmacokinetics and Safety of ASC16 Tablets in Healthy Volunteers in China Danoprevir, Ritonavir, Ravidasvir - HCV	Phase 1	Completed	Ascletis Pharmaceuticals Co., Ltd.	18	2017-08-08	2018-01-17
Pharmacokinetics and Safety of Ravidasvir and Danoprevir/r in Healthy Volunteers China Ravidasvir, Danoprevir, Ritonavir - Healthy	Phase 1	Completed	Ascletis Pharmaceuticals Co., Ltd.	18	2016-07-15	2018-06-29
Safety, Tolerability and Pharmacokinetics of Danoprevir/r in Healthy Volunteers China Danoprevir, Ritonavir, Placebo - Healthy	Phase 1	Completed	Ascletis Pharmaceuticals Co., Ltd.	18	2015-10-01	2017-01-13
A Safety And Pharmacokinetic Study of Setrobuvir Alone and In Combination With Ritonavir-Boosted Danoprevir in Subjects With Mild Hepatic Impairment Compared to Healthy Controls danoprevir, ritonavir, setrobuvir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	18	2012-11-01	2016-11-02
A Pharmacokinetic And Bioavailability Study of Intravenous Danoprevir in Healthy Volunteers danoprevir, placebo, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	33	2012-07-01	2016-11-02
A Study of Drug-Drug Interaction Between Danoprevir Coadministered With Low-Dose Ritonavir and Tenofovir Disoproxil Fumarate or Atazanavir atazanavir, danoprevir, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	40	2012-05-01	2016-11-02
A Study of The Relative Bioavailability of Ritonavir-Boosted Danoprevir Fixed Dose Combination Tablets in Healthy Volunteers danoprevir, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	42	2012-05-01	2016-11-02
A Study of Potential Drug-Drug Interaction Between Efavirenz and Danoprevir With Low Dose Ritonavir in Healthy Volunteers danoprevir, efavirenz, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	40	2012-04-01	2016-11-02
A Study of Drug-Drug Interaction Between Darunavir and Danoprevir Administered Together With Low-Dose Ritonavir in Healthy Volunteers danoprevir, darunavir, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	40	2012-02-01	2016-11-02
A Study of Drug-Drug Interaction Between Danoprevir/Low-Dose Ritonavir and Raltegravir in Healthy Volunteers danoprevir, raltegravir, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	20	2012-01-01	2016-11-02
A Drug-Drug Interaction Study Between Danoprevir/Low-Dose Ritonavir and Cyclosporine in Healthy Volunteers cyclosporine, danoprevir, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	18	2011-12-01	2016-11-02
A Relative Bioavailability Study of Danoprevir and Ritonavir in Healthy Volunteers danoprevir, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	36	2011-12-01	2016-11-02
A Study to Evaluate the Effect of Danoprevir/Ritonavir on the Pharmacokinetics of Escitalopram and S-Demethylcitalopram in Healthy Volunteers danoprevir, escitalopram, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	20	2011-08-01	2016-11-02
A Study of Danoprevir in Combination With Low-Dose Ritonavir in Healthy Subjects danoprevir, danoprevir placebo, moxifloxacin - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	52	2011-08-01	2016-11-02
A Study to Evaluate The Effects of Two Different Meal Types, Omeprazole And Ranitidine On Danoprevir Pharmacokinetics When Coadministered With Ritonavir in Healthy Volunteers danoprevir, omeprazole, ranitidine - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	32	2011-07-01	2016-11-02
A Study on the Interaction Between Danoprevir/Ritonavir and Methadone danoprevir, methadone, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	18	2011-06-01	2016-11-02
A Study of Danoprevir in Healthy Volunteers And Patients With Hepatic Impairment danoprevir, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	81	2011-02-01	2016-11-02
A Study of RO5190591 (Danoprevir) in Healthy Volunteers danoprevir, ketoconazole, ritonavir - Healthy Volunteer	Phase 1	Completed	Hoffmann-La Roche	18	2010-07-01	2016-08-29
A Study of Ritonavir-Boosted Danoprevir (RO5190591) in Combination With Pegasys and Ribavirin in Patients With Chronic Hepatitis C Genotype 1 danoprevir, peginterferon alfa-2a [Pegasys], placebo - Hepatitis C, Chronic	Phase 1	Completed	Hoffmann-La Roche	59	2009-08-01	2016-11-02
A Study of Combination Treatment With an HCV Polymerase Inhibitor (RO5024048) and an HCV Protease Inhibitor (RO5190591/Danoprevir) in Genotype 1 Chronic Hepatitis C Patients RO5024048, danoprevir - Hepatitis C, Chronic	Phase 1	Completed	Hoffmann-La Roche	88	2008-11-01	2016-11-02

Conditions studied

Hepatitis C, Chronic (2)

Sponsors

Hoffmann-La Roche (17)  ·  Ascletis Pharmaceuticals Co., Ltd. (3)

Countries

United States (10)  ·  New Zealand (4)  ·  France (2)  ·  Poland (2)  ·  Australia (1)  ·  China (1)  ·  Czechia (1)  ·  Hungary (1)  ·  Netherlands (1)  ·  Slovakia (1)

Top investigators

Huoling Tang, PhD (2)

Results publications

PMID 20951424, PMID 21354234, PMID 23712757, PMID 23872824, PMID 24295986, PMID 34252301

NIH funding

2009 (1)