3 completed, 1 recruiting, 1 unknown. 3 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow Cytochrome P-450 CYP2C19: new trials by email Literature Review of Cytochrome P-450 CYP2C19 trials Research Report on Cytochrome P-450 CYP2C19
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Olutasidenib DDI Study in Patients With IDH1 Mutation Positive Malignancies Olutasidenib, CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, and OATP1B1 Probe Substrates - AML (Acute Myeloid Leukemia), Glioma | Phase 4 | Recruiting | Rigel Pharmaceuticals | 16 | 2026-02-23 | 2026-08-11 |
| The Influence of Gene Polymorphism on Clinical Outcomes in Patients Undergoing PCI CYP2C19 - Antiplatelet Therapy, CYP2C19 Polymorphism | Unknown | Beijing Anzhen Hospital | 12000 | 2018-12-01 | 2020-12-08 | |
| Effects of AZD1775 on the PK Substrates for CYP3A, CYP2C19, CYP1A2 and on QT Interval in Patients With Advanced Cancer CYP1A2 (caffeine), CYP2C19 (omeprazole), CYP3A (midazolam) - Solid Tumours | Phase 1 | Completed | AstraZeneca | 33 | 2017-12-01 | 2019-03-25 |
| Pharmacogenetic and Pharmacokinetics of Naproxen and Associated Naproxen-esomeprazole Naproxen, Naproxen-esomeprazole - Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant, Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant | Phase 4 | Completed | University of Sao Paulo | 8 | 2017-03-01 | 2020-11-03 |
| Adjunctive Cilostazol Versus High Maintenance-dose ClopidogrEL in Acute Myocardial Infarction (AMI) Patients According to CYP2C19 Polymorphism cilostazol, clopidogrel (Plavix), CYP2C19 - Myocardial Infarction | Phase 4 | Completed | Gyeongsang National University Hospital | 80 | 2009-05-01 | 2009-11-10 |
Cholangiocarcinoma (1) · Glioma (1) · Leukemia, Myeloid, Acute (1) · Myocardial Infarction (1) · Neoplasms (1)
AstraZeneca (1) · Beijing Anzhen Hospital (1) · Gyeongsang National University Hospital (1) · Rigel Pharmaceuticals (1) · University of Sao Paulo (1)
United States (2) · Brazil (1) · China (1) · South Korea (1)
Adriana M Calvo, PhD (1) · Ding Wang, MD (1) · In-Suk Kim, MD.PhD. (1) · Lone Ottesen, MD (1) · Yujie Zhou, PhD,MD (1)
PMID 16286167, PMID 17261652, PMID 17697815, PMID 18355656, PMID 18567918, PMID 19106084, PMID 19108880, PMID 19220726, PMID 19324253, PMID 19414633, PMID 20650435, PMID 21511217, PMID 22007612, PMID 22837373, PMID 23517020, PMID 37368100, PMID 37394627