6 completed, 1 terminated. 3 Phase 3, 2 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Completed 2, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 2 | 2 | Completed 2 |
Follow clazosentan: new trials by email Literature Review of clazosentan trials Research Report on clazosentan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrowing of the Blood Vessels (Vasospasm) in the Brain, Caused by Bleeding Onto the Surface of the Brain Clazosentan, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 3 | Completed | Idorsia Pharmaceuticals Ltd. | 409 | 2019-02-03 | 2024-01-10 |
| A Study in Healthy Subjects to Investigate Whether Administration of Clazosentan Can Affect Normal Heart Function Clazosentan, Placebo, Moxifloxacin - Healthy Subjects | Phase 1 | Completed | Idorsia Pharmaceuticals Ltd. | 36 | 2018-09-18 | 2018-11-20 |
| A Study in Healthy Male Subjects to Investigate Whether Administration of Rifampicin Can Affect the Fate of Clazosentan in the Body of Clazosentan Clazosentan, Rifampicin, Saline (0.9% sodium chloride) - Healthy Subjects | Phase 1 | Completed | Idorsia Pharmaceuticals Ltd. | 14 | 2018-07-19 | 2018-10-23 |
| Evaluation of the Efficacy and Safety of Clazosentan in Reversing Cerebral Vasospasm in Adult Subjects With Aneurysmal Subarachnoid Hemorrhage Clazosentan - Aneurysmal Subarachnoid Hemorrhage | Phase 2 | Completed | Idorsia Pharmaceuticals Ltd. | 25 | 2016-03-01 | 2018-07-10 |
| Clazosentan in Aneurysmal Subarachnoid Hemorrhage Clazosentan 5 m/h, Clazosentan 15 mg/h, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 3 | Terminated | Idorsia Pharmaceuticals Ltd. | 577 | 2009-07-01 | 2018-07-09 |
| Clazosentan in Reducing Vasospasm-related Morbidity and All-cause Mortality in Adult Patients With Aneurysmal Subarachnoid Hemorrhage Treated by Surgical Clipping Clazosentan, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 3 | Completed | Idorsia Pharmaceuticals Ltd. | 1157 | 2007-12-14 | 2020-02-17 |
| Clazosentan in Preventing the Occurrence of Cerebral Vasospasm Following an Aneurysmal Subarachnoid Hemorrhage (aSAH) Clazosentan 1 mg/h, Clazosentan 5 mg/h, Clazosentan 15 mg/h - Aneurysmal Subarachnoid Hemorrhage | Phase 2 | Completed | Idorsia Pharmaceuticals Ltd. | 413 | 2005-01-10 | 2018-07-10 |
Subarachnoid Hemorrhage (5) · Vasospasm, Intracranial (3) · Hemorrhage (2)
Idorsia Pharmaceuticals Ltd. (7)
Canada (4) · Finland (4) · France (4) · United States (4) · Austria (3) · Belgium (3) · Czechia (3) · Denmark (3) · Germany (3) · Italy (3) · Netherlands (3) · Poland (3) · Spain (3) · Sweden (3) · Switzerland (3)
Angelina Marr, BSc. Pharm (1) · Sebastien Roux, MD (1)
PMID 31394993, PMID 21640651, PMID 21998061, PMID 22403047, PMID 22678087, PMID 22890639, PMID 23581590, PMID 24425125, PMID 25280913, PMID 26248048, PMID 26428322, PMID 27000643, PMID 27827324, PMID 29946013, PMID 31299650, PMID 33389549, PMID 36539711, PMID 39126720
2018 (3), 2015 (1)