12 completed, 1 unknown. 9 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 8, Unknown 1 |
| Phase 1 | 4 | Completed 4 |
Follow Bryostatins: new trials by email Literature Review of Bryostatins trials Research Report on Bryostatins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Bryostatin in Moderately Severe to Severe Alzheimer's Disease Subjects Not On Memantine Bryostatin, Placebo - Alzheimer Disease | Phase 2 | Completed | Neurotrope Bioscience, Inc. | 108 | 2018-06-20 | 2020-10-01 |
| A Study Assessing Bryostatin in the Treatment of Moderately Severe to Severe Alzheimer's Disease Bryostatin 1, Placebo - Alzheimer's Disease | Phase 2 | Completed | Neurotrope Bioscience, Inc. | 147 | 2015-11-01 | 2018-07-06 |
| Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics Study of Bryostatin 1 in Patients With Alzheimer's Disease Bryostatin for Injection, Placebo - Alzheimer's Disease | Phase 2 | Unknown | Blanchette Rockefeller Neurosciences Insitute | 9 | 2008-04-01 | 2008-02-01 |
| Temsirolimus and Bryostatin 1 in Treating Patients With Unresectable or Metastatic Solid Tumors bryostatin 1, temsirolimus - Recurrent Melanoma, Recurrent Renal Cell Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2005-03-01 | 2013-05-03 |
| Bryostatin 1 Plus Vincristine in Treating Patients With Progressive or Relapsed Non-Hodgkin's Lymphoma After Bone Marrow or Stem Cell Transplantation bryostatin 1, vincristine sulfate, laboratory biomarker analysis - Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue, Nodal Marginal Zone B-cell Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 28 | 2003-03-01 | 2013-01-10 |
| Paclitaxel and Bryostatin 1 in Treating Patients With Advanced Pancreatic Cancer paclitaxel, bryostatin 1 - Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas | Phase 2 | Completed | National Cancer Institute (NCI) | 19 | 2002-03-01 | 2021-06-11 |
| Interleukin-2 and Bryostatin 1 in Treating Patients With Advanced Kidney Cancer aldesleukin, bryostatin 1, laboratory biomarker analysis - Recurrent Renal Cell Cancer, Stage III Renal Cell Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 65 | 2002-01-01 | 2013-01-24 |
| Bryostatin 1 Plus Vincristine in Treating Patients With Recurrent or Refractory HIV-Related Lymphoma bryostatin 1, vincristine sulfate - AIDS-related Diffuse Large Cell Lymphoma, AIDS-related Diffuse Mixed Cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 12 | 2001-11-01 | 2013-01-25 |
| Chemotherapy Plus Sargramostim in Treating Patients With Refractory Myeloid Cancer bryostatin 1, sargramostim, laboratory biomarker analysis - Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Phase 1 | Completed | National Cancer Institute (NCI) | 35 | 2001-03-01 | 2013-01-09 |
| Bryostatin 1 and Cisplatin in Treating Patients With Advanced Recurrent or Residual Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer bryostatin 1, cisplatin, laboratory biomarker analysis - Fallopian Tube Cancer, Primary Peritoneal Cavity Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 32 | 2000-10-01 | 2013-08-26 |
| Bryostatin 1 and Cisplatin in Treating Patients With Metastatic or Unresectable Stomach Cancer bryostatin 1, cisplatin, laboratory biomarker analysis - Stage III Gastric Cancer, Stage IV Gastric Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 12 | 2000-10-01 | 2014-10-01 |
| Combination Chemotherapy in Treating Patients With Unresectable Locally Advanced or Metastatic Stomach Cancer Bryostatin-1, Paclitaxel (Taxol) - Esophageal Cancer, Gastric Cancer | Phase 2 | Completed | M.D. Anderson Cancer Center | 37 | 2000-06-01 | 2012-07-30 |
| Bryostatin and Vincristine in B-Cell Malignancies bryostatin 1, vincristine sulfate, laboratory biomarker analysis - Recurrent Adult Burkitt Lymphoma, Recurrent Adult Diffuse Large Cell Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 18 | 1998-05-01 | 2013-01-11 |
Alzheimer Disease (3) · Carcinoma, Renal Cell (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Lymphoma, Follicular (2) · Lymphoma, Large B-Cell, Diffuse (2) · Lymphoma, Mantle-Cell (2) · Lymphoma, Non-Hodgkin (2) · Stomach Neoplasms (2) · Adenocarcinoma Of Esophagus (1) · Anemia, Refractory (1) · Blast Crisis (1) · Burkitt Lymphoma (1) · Carcinoma, Ovarian Epithelial (1) · Congenital Abnormalities (1) · Esophageal Neoplasms (1)
National Cancer Institute (NCI) (9) · Neurotrope Bioscience, Inc. (2) · Blanchette Rockefeller Neurosciences Insitute (1) · M.D. Anderson Cancer Center (1)
United States (13)
Brenda Cooper (2) · Alan Tuchman, MD (1) · Andreas Kaubisch (1) · B. Smith (1) · Gary Hudes (1) · Heinz-Josef Lenz (1) · Jaffer A. Ajani, MD (1) · James M Stevenson, MD (1) · Robert Morgan (1) · Scot Remick (1) · Walter Stadler (1)
N01CM17101 (2), U01CA062502 (2), N01CM17102 (1), N01CM17103 (1), P01CA015396 (1), P30CA016672 (1), U01CA070019 (1), U01CA070172 (1)