5 completed, 1 recruiting. 4 Phase 2, 3 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Completed 3, Recruiting 1 |
| Phase 1 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 2 |
Follow Berinert: new trials by email Literature Review of Berinert trials Research Report on Berinert
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Improving Deceased-Donor Kidney Transplant Outcomes Via a Single Intragraft Injection of C1 Esterase Inhibitor (IMPROVE TRIAL) Berinert, Placebo for Berinert - Kidney Transplant | Phase 2 | Recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 180 | 2025-09-22 | 2026-02-27 |
| Berinert (C1INH) vs Placebo for DGF/IRI Berinert, Placebo - End Stage Renal Disease, Chronic Kidney Diseases | Phase 1 / Phase 2 | Completed | Cedars-Sinai Medical Center | 45 | 2021-03-03 | 2024-12-04 |
| Randomized, Double-blind, Two Arms, Multicenter, Phase III Study of Berinert for Treatment of ACE Induced Angioedema Berinert, Clemastin, Cortisone acetate - Acute ACE-induced Angioedema | Phase 3 | Completed | Technical University of Munich | 31 | 2013-11-01 | 2023-11-24 |
| A Study to Evaluate the Safety and Pharmacokinetics of Two Formulations of C1-esterase Inhibitor Berinert, CSL830 - Hereditary Angioedema Types I and II | Phase 1 | Completed | CSL Behring | 16 | 2013-01-01 | 2013-04-05 |
| Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection C1 Esterase Inhibitor, Placebos - Kidney Transplantation | Phase 1 / Phase 2 | Completed | Stanley Jordan, MD | 20 | 2011-08-01 | 2017-03-21 |
| Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks C1 Esterase Inhibitor, Placebo - Hereditary Angioedema | Phase 2 / Phase 3 | Completed | CSL Behring | 126 | 2005-06-01 | 2015-03-31 |
Angioedemas, Hereditary (2) · Hereditary Angioedema Types I and II (1) · Kidney Failure, Chronic (1) · Renal Insufficiency, Chronic (1)
CSL Behring (2) · Cedars-Sinai Medical Center (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Stanley Jordan, MD (1) · Technical University of Munich (1)
United States (4) · Germany (2) · Argentina (1) · Australia (1) · Bulgaria (1) · Canada (1) · Czechia (1) · Hungary (1) · Israel (1) · North Macedonia (1) · Poland (1) · Romania (1) · Russia (1) · Spain (1) · Sweden (1)
Murat Bas, Dr. (1) · Peter S Heeger, MD (1) · Sindhu Chandran, MBBS, MD (1) · Stanley C Jordan, MD (1) · Stanley Jordan, MD (1)
PMID 19767078, PMID 20674826, PMID 23987198, PMID 25606785, PMID 40349965, PMID 40972903
2004 (1)