5 active not recruiting, 3 recruiting. 8 Phase 3.
By phase and status
Follow belzutifan: new trials by email Literature Review of belzutifan trials Research Report on belzutifan
Trials (filtered) newest first · largest first
All 8 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
A Clinical Study of Belzutifan (MK-6482) and Zanzalintinib in People With Renal Cell Carcinoma (RCC) (LITESPARK-034/LS-034/MK-6482-034) Belzutifan, Zanzalintinib, Placebo - Carcinoma, Renal Cell | Phase 3 | Recruiting | 758 | 2026-04-09 | 2026-10-29 |
Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043) Belzutifan, Nivolumab, Lenvatinib - Von Hippel-Lindau Disease, Malignant Neoplasms | Phase 3 | Recruiting | 450 | 2026-03-23 | 2026-10-21 |
A Clinical Study of Belzutifan and Zanzalintinib in People With Recurrent Kidney Cancer Following Adjuvant Therapy (MK-6482-033) Belzutifan, Zanzalintinib, Cabozantinib - Renal Cell Carcinoma | Phase 3 | Recruiting | 904 | 2025-11-26 | 2026-08-03 |
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, vs Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012)-China Extension Study Pembrolizumab, Belzutifan, Pembrolizumab/Quavonlimab - Carcinoma, Renal Cell | Phase 3 | Active not recruiting | 251 | 2022-07-27 | 2026-08-20 |
A Study of Belzutifan (MK-6482) Plus Pembrolizumab (MK-3475) Versus Placebo Plus Pembrolizumab in Participants With Clear Cell Renal Cell Carcinoma Post Nephrectomy (MK-6482-022) Belzutifan, Pembrolizumab, Placebo - Carcinoma, Renal Cell | Phase 3 | Active not recruiting | 1800 | 2022-03-15 | 2026-05-15 |
A Study of Pembrolizumab (MK-3475) in Combination With Belzutifan (MK-6482) and Lenvatinib (MK-7902), or Pembrolizumab/Quavonlimab (MK-1308A) in Combination With Lenvatinib, Versus Pembrolizumab and Lenvatinib, for Treatment of Advanced Clear Cell Renal Cell Carcinoma (MK-6482-012) Pembrolizumab, Belzutifan, Pembrolizumab/Quavonlimab - Carcinoma, Renal Cell | Phase 3 | Active not recruiting | 1688 | 2021-04-14 | 2026-10-02 |
A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011) Belzutifan, Lenvatinib, Cabozantinib - Carcinoma, Renal Cell | Phase 3 | Active not recruiting | 747 | 2021-02-25 | 2026-05-05 |
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005) Belzutifan, Everolimus - Carcinoma, Renal Cell | Phase 3 | Active not recruiting | 755 | 2020-02-27 | 2026-10-20 |
Conditions studied
Carcinoma, Renal Cell (7) · Parkinson Disease 4, Autosomal Dominant Lewy Body (3) · Carcinoma (1) · Kidney Neoplasms (1) · Neoplasms (1) · von Hippel-Lindau Disease (1)
Sponsors
Merck Sharp & Dohme LLC (8)
Countries
Brazil (7) · Chile (7) · Czechia (7) · France (7) · South Korea (7) · Spain (7) · United Kingdom (7) · United States (7) · Australia (6) · Canada (6) · Germany (6) · Italy (6) · Poland (6) · Denmark (5) · Finland (5)
Results publications
PMID 36064785, PMID 36752726, PMID 37882432, PMID 39167807, PMID 40112850, PMID 42384869, PMID 42586114
NIH funding
2023 (2), 2019 (1), 2025 (1)