4 completed, 1 unknown, 1 withdrawn. 2 Phase 2, 2 Phase 4, 1 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 2 | Completed 2 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
| Not applicable | 1 | Withdrawn 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Atovaquone-Proguanil: new trials by email Literature Review of Atovaquone-Proguanil trials Research Report on Atovaquone-Proguanil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy, Safety, and PK of M5717 in Combination With Pyronaridine as Chemoprevention in Adults and Adolescents With Asymptomatic Plasmodium Falciparum Infection (CAPTURE-2) M5717 60 mg, Pyronaridine, Atovaquone-Proguanil - Malaria Infection | Phase 2 | Completed | Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany | 192 | 2023-11-28 | 2026-02-06 |
| A Clinical Trial to Evaluate Plasmodium Falciparum 7G8 and NF54 Challenge Strains (PfSPZ) in a Head-to-head Comparative Study - (ECG-CHMI) atovaquone-proguanil - Plasmodium Falciparum | Not applicable | Withdrawn | U.S. Army Medical Research and Development Command | 2020-03-01 | 2020-05-08 | |
| Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1 Sulfadoxine-pyrimethamine (low dose), Piperaquine (low dose), Sulfadoxine-pyrimethamine (high dose) - Malaria | Phase 1 / Phase 2 | Completed | Radboud University Medical Center | 29 | 2016-06-01 | 2018-03-23 |
| The ASAP Study - Therapeutic Efficacy of Atovaquone-proguanil vs. Artesunate-atovaquone-proguanil in Cambodia atovaquone-proguanil, artesunate-atovaquone-proguanil - Malaria | Phase 4 | Unknown | Armed Forces Research Institute of Medical Sciences, Thailand | 205 | 2014-12-01 | 2021-03-02 |
| Evaluation of Potential Effect of Artemether - Lumefantrine and Malaria Drugs on Auditory Function Artesunate-mefloquine, Atovaquone-proguanil, Artemether-lumefantrine - Malaria, Falciparum | Phase 4 | Completed | Novartis | 265 | 2007-05-01 | 2011-04-05 |
| Chloroquine Alone or in Combination for Malaria in Children in Malawi Atovaquone-proguanil, Artesunate, Azithromycin - Plasmodium Falciparum Infection | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 640 | 2007-02-01 | 2014-08-11 |
Malaria (5) · Malaria, Falciparum (4) · Asymptomatic Infections (1)
Armed Forces Research Institute of Medical Sciences, Thailand (1) · Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Novartis (1) · Radboud University Medical Center (1) · U.S. Army Medical Research and Development Command (1)
Burkina Faso (1) · Cambodia (1) · Colombia (1) · Kenya (1) · Malawi (1) · Netherlands (1) · The Gambia (1) · Zambia (1)
Lek Dysoley, MD (1) · Mariusz Wojnarski, MD (1)