11 completed, 1 withdrawn. 10 Phase 2, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 9, Withdrawn 1 |
| Phase 1 | 2 | Completed 2 |
Follow AS03: new trials by email Literature Review of AS03 trials Research Report on AS03
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| COVID-19 Variant Immunologic Landscape Trial (COVAIL Trial) AS03, BNT162b2, BNT162b2 (B.1.1.529) - COVID-19 | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 1270 | 2022-03-30 | 2025-10-20 |
| 2017 A/H7N9 IIV Revaccination A/H7N9, AS03, Phosphate Buffered Saline (PBS) diluent - Avian Influenza, Influenza Immunisation | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 304 | 2018-12-18 | 2021-07-30 |
| 2013/2017 H7N9 Prime-Boost Interval A/H7N9, AS03, Influenza Virus Vaccine, Monovalent A/H7N9 A/Shanghai/2/2013 - Avian Influenza, Influenza Immunisation | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 180 | 2018-08-21 | 2021-08-02 |
| Co-Administration of AS03 Adjuvanted A/H7N9 IIV With IIV4 AS03, Inactivated influenza H7N9 vaccine, Influenza Virus Quadrivalent Inactivated Vaccine - Avian Influenza, Influenza | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 149 | 2018-02-20 | 2020-08-06 |
| Sanofi 2017 H7N9 With/Without AS03 in Adults/Elderly AS03, Inactivated influenza H7N9 vaccine, Phosphate Buffered Saline (PBS) diluent - Avian Influenza, Influenza Immunisation | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 720 | 2018-02-14 | 2024-09-19 |
| Panblok H7 Vaccine Adjuvanted With AS03 or MF59 3.75 ug Panblok H7, 7.5 ug Panblok H7, 15 ug Panblok H7 - Influenza, Human | Phase 2 | Completed | Biomedical Advanced Research and Development Authority | 366 | 2017-09-20 | 2020-05-06 |
| H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults: Immunology AS03, MF59, Monovalent Influenza A/H5N8 vaccine - Avian Influenza | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 388 | 2017-01-09 | 2024-09-23 |
| H7N9 Vaccination With and Without AS03 and Unadjuvanted H3N2v Vaccination: Standard and Systems Biology Analyses AS03, Influenza Virus Vaccine, Monovalent A/H3N2v A/Minnesota/11/2010 NYMC X-203, Monovalent influenza A/H7N9 virus vaccine - Avian Influenza, H1N1 Influenza | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 30 | 2016-11-07 | 2024-10-09 |
| H5N8 Mix and Match With or Without AS03 or MF59 in Healthy Adults AS03, MF59 adjuvant, Monovalent Influenza A/H5N8 vaccine - Avian Influenza, Influenza | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 276 | 2016-08-16 | 2019-10-23 |
| H7N9 Mix and Match With AS03 and MF59 in Healthy Adults AS03, MF59, Influenza Virus Vaccine, Monovalent A/H7N9 A/Shanghai/2/2013 - Influenza | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 980 | 2013-09-01 | 2017-07-06 |
| Sanofi H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations AS03, Influenza Virus Vaccine, Monovalent A/H1N1 A/California/7/2009 NYMC X-179A - Influenza | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 789 | 2009-09-01 | 2014-12-24 |
| CSL H1N1 Influenza Vaccine Administered at Different Dose Levels With and Without AS03 Adjuvant in Healthy Adult and Elderly Populations AS03, Inactivated H1N1 Vaccine - Influenza | Phase 2 | Withdrawn | National Institute of Allergy and Infectious Diseases (NIAID) | 2018-10-16 |
Influenza, Human (11) · Influenza in Birds (8) · Orthomyxoviridae Infections (2) · COVID-19 (1) · RNA Virus Infections (1) · Respiratory Tract Diseases (1) · Respiratory Tract Infections (1) · Virus Diseases (1)
National Institute of Allergy and Infectious Diseases (NIAID) (11) · Biomedical Advanced Research and Development Authority (1)
United States (11)
Carlos Fierro, MD (1) · Mark Adams, MD (1) · Matthew Davis, MD (1) · Terry Poling, MD (1)
PMID 39756216, PMID 22782949, PMID 26197184, PMID 35465983, PMID 35898343, PMID 37205592, PMID 37466221, PMID 37640860, PMID 38537255, PMID 39325506, PMID 40930044, PMID 41698311, PMID 42630599
5UM1AI148684-03 (1)