artefenomel: Clinical Trials

3 completed, 2 terminated. 5 Phase 2, 1 Phase 1, 1 Phase 3.

By phase and status

Phase	Trials	Status
Phase 2	5	Completed 3, Terminated 2
Phase 1	1	Terminated 1
Phase 3	1	Completed 1

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Trials (filtered) newest first · largest first

All 5 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum Malaria Artefenomel (OZ439), Ferroquine (SSR97193) - Plasmodium Falciparum Infection	Phase 2	Completed	Sanofi	140	2018-09-11	2022-03-21
A Study to Characterise the Antimalarial and Transmission Blocking Activity of a Single Dose of DSM265 or OZ439 in Healthy Subjects With Induced Blood Stage Plasmodium Falciparum or Plasmodium Vivax Infection DSM265, OZ439 - Malaria	Phase 1 / Phase 2	Terminated	Medicines for Malaria Venture	16	2015-10-01	2020-06-05
To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Single Dose Regimen of Ferroquine and Artefenomel in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria Ferroquine SSR97193, Artefenomel, Placebo - Plasmodium Falciparum Infection	Phase 2	Terminated	Sanofi	377	2015-07-25	2022-03-24
Phase II Efficacy Study of Artefenomel & Piperaquine in Adults & Children With P. Falciparum Malaria. Artefenomel 800mg: piperaquine 640mg, Artefenomel 800mg: piperaquine 960mg, Artefenomel 800mg: piperaquine 1440mg - Uncomplicated Plasmodium Falciparum Malaria	Phase 2 / Phase 3	Completed	Medicines for Malaria Venture	448	2014-07-01	2017-03-10
Efficacy, Tolerability, PK of OZ439 in Adults With Acute, Uncomplicated P.Falciparum or Vivax Malaria Mono-infection OZ439 - Malaria, Falciparum, Malaria, Vivax	Phase 2	Completed	Medicines for Malaria Venture	82	2010-10-01	2014-12-03

Conditions studied

Malaria (2)  ·  Malaria, Falciparum (2)  ·  Malaria, Vivax (1)

Sponsors

Medicines for Malaria Venture (3)  ·  Sanofi (2)

Countries

Benin (3)  ·  Burkina Faso (3)  ·  Gabon (3)  ·  Uganda (3)  ·  Kenya (2)  ·  Mozambique (2)  ·  Vietnam (2)  ·  Australia (1)  ·  Democratic Republic of the Congo (1)

Top investigators

Fiona Macintyre, PhD (1)  ·  James McCarthy, Prof (1)  ·  Michael Ramharter, MD (1)  ·  Sasithon Pukrittayakamee, MD (1)

Results publications

PMID 26448141, PMID 28988541, PMID 30858218, PMID 30967148, PMID 32479608, PMID 34011358, PMID 34179977, PMID 36597076