5 completed, 1 no longer available, 1 terminated. 3 Phase 1, 2 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 1, Terminated 1 |
Follow ABT-414: new trials by email Literature Review of ABT-414 trials Research Report on ABT-414
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| UNITE Study: Understanding New Interventions With GBM ThErapy Steroid eye drops, Vasoconstrictor eye drops, Cold compress - Glioblastoma Multiforme | Phase 3 | Terminated | AbbVie | 40 | 2018-07-30 | 2021-04-14 |
| Study Evaluating ABT-414 in Japanese Subjects With Malignant Glioma Whole Brain Radiation, Temozolomide, ABT-414 - Malignant Glioma, Glioblastoma Multiforme | Phase 1 / Phase 2 | Completed | AbbVie | 53 | 2015-08-24 | 2020-09-03 |
| Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas Depatuxizumab mafodotin, Temozolomide, Lomustine - Glioblastoma | Phase 2 | Completed | AbbVie | 266 | 2015-02-17 | 2020-05-22 |
| A Study of ABT-414 in Participants With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification Temozolomide, Depatuxizumab mafodotin, Radiation - Glioblastoma, Gliosarcoma | Phase 3 | Completed | AbbVie | 691 | 2015-01-04 | 2023-05-11 |
| Evaluating the Safety and Pharmacokinetics of ABT-414 for Subjects With Glioblastoma Multiforme ABT-414, Temozolomide, Whole Brain Radiation - Glioblastoma Multiforme | Phase 1 | Completed | AbbVie | 202 | 2013-04-02 | 2017-11-21 |
| A Study of ABT-414 in Subjects With Solid Tumors ABT-414 - Squamous Cell Tumors | Phase 1 | Completed | AbbVie (prior sponsor, Abbott) | 57 | 2012-10-01 | 2017-11-20 |
| Expanded Access to ABT-414 ABT-414 - Glioblastoma or Solid Tumors, Epidermal Growth Factor Receptor (EGFR) Diagnosis | No longer available | AbbVie | 2019-07-15 |
Glioblastoma (6) · Brain Neoplasms (2) · Disease (1) · Glioma (1) · Gliosarcoma (1) · Lymphoma, Follicular (1) · Neoplasms (1)
AbbVie (6) · AbbVie (prior sponsor, Abbott) (1)
United States (4) · Australia (3) · Canada (3) · Germany (3) · Netherlands (3) · United Kingdom (3) · Austria (2) · Belgium (2) · Czechia (2) · France (2) · Ireland (2) · Italy (2) · Mexico (2) · Singapore (2) · South Korea (2)
Christopher Ocampo, MD (1) · Earle Bain, MD (1)
PMID 29982805, PMID 28039367, PMID 29077941, PMID 28349167, PMID 29533458, PMID 30796037, PMID 31747009, PMID 33601293, PMID 34609773
2014 (1), 2015 (1), 2017 (1)