4 completed, 3 terminated. 6 Phase 1, 6 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 6 | Completed 4, Terminated 2 |
| Phase 2 | 6 | Completed 4, Terminated 2 |
| Early Phase 1 | 1 | Terminated 1 |
Follow 6MHP: new trials by email Literature Review of 6MHP trials Research Report on 6MHP
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Melanoma Vaccine Against Neoantigen and Shared Antigens by CD40 Activation and TLR Agonists In Patients With Melanoma (Including Ocular Melanoma) 6MHP, NeoAg-mBRAF, PolyICLC - Melanoma, Ocular Melanoma | Phase 1 / Phase 2 | Completed | Craig L Slingluff, Jr | 22 | 2020-09-28 | 2024-07-16 |
| Vaccination With 6MHP, With or Without Systemic CDX-1127, in Patients With Stage II-IV Melanoma 6MHP, Montanide ISA-51, polyICLC - Melanoma | Phase 1 / Phase 2 | Completed | Craig L Slingluff, Jr | 33 | 2018-11-13 | 2024-02-06 |
| Safety Study of a Helper Peptide Vaccine Plus Pembrolizumab 6MHP, Pembrolizumab - Melanoma | Phase 1 / Phase 2 | Completed | Craig L Slingluff, Jr | 22 | 2016-10-06 | 2023-08-25 |
| A Clinical Trial to Evaluate a Melanoma Helper Peptide Vaccine Plus Dabrafenib and Trametinib BRAF inhibitor, 6MHP, MEK inhibitor - Melanoma | Early Phase 1 | Terminated | Craig L Slingluff, Jr | 8 | 2016-04-01 | 2023-12-12 |
| Safety Study of a Helper Peptide Vaccine Plus Adjuvant Combinations for the Treatment of Melanoma 6MHP, Montanide ISA-51, polyICLC - Melanoma | Phase 1 / Phase 2 | Terminated | Craig L Slingluff, Jr | 48 | 2015-05-12 | 2023-10-30 |
| A Phase I/II Trial to Evaluate a Peptide Vaccine Plus Ipilimumab in Patients With Melanoma Ipilimumab, 6MHP - Melanoma | Phase 1 / Phase 2 | Terminated | Craig L Slingluff, Jr | 3 | 2015-04-01 | 2020-05-05 |
| Vaccine Therapy in Treating Patients With Stage IIIB, Stage IIIC, or Stage IV Melanoma IFA, 6MHP, GM-CSF - Intraocular Melanoma, Melanoma (Skin) | Phase 1 / Phase 2 | Completed | University of Virginia | 39 | 2003-07-01 | 2014-11-20 |
Melanoma (7) · Uveal Melanoma (2) · Nevus (1)
Craig L Slingluff, Jr (6) · University of Virginia (1)
United States (7)
Craig L. Slingluff, Jr., MD (5) · Elizabeth Gaughan, MD (2) · Craig L Slingluff, Jr., MD (1) · Craig L. Slingluff, MD (1)
PMID 18809608, PMID 25126421, PMID 28851380, PMID 41775435
R01CA178846 (2)