4 recruiting, 3 active not recruiting, 3 completed, 1 enrolling by invitation. 3 Phase 3, 1 Not applicable, 1 Phase 1, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Active not recruiting 2, Terminated 1 |
| Not applicable | 1 | Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 4 | 1 | Active not recruiting 1 |
Follow Mpox: new trials by email Literature Review of Mpox trials Research Report on Mpox
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mpox Biology, Outcome, Transmission and Epidemiology - Tracking the Immune Response After mpoX vaCcination (MBOTE-TRAXX): Clinical Study to Monitor the Immunological Response Following Mpox Vaccination in the City of Kinshasa, Democratic Republic of the Congo blood sample collection - Mpox | Phase 4 | Active not recruiting | Institute of Tropical Medicine, Belgium | 300 | 2026-05-15 | 2026-06-11 |
| Validation of SDS-EDTA-Treated Chromatography Paper Strips for Mpox Sampling and Transport in DRC SDS-EDTA-treated chromatography strip - Mpox | Recruiting | Universitaire Ziekenhuizen KU Leuven | 150 | 2026-05-01 | 2026-06-11 | |
| Evaluation of Effectiveness and Safety of LC16m8 Mpox Vaccine in the Democratic Republic of Congo (DRC) LC16m8 - Mpox (Monkeypox), Mpox | Recruiting | International Vaccine Institute | 11990 | 2025-12-03 | 2026-08-31 | |
| Phase 3 Maternal Safety & Immunogenicity Trial of MVA-BN® in DRC MVA-BN standard regimen, MVA-BN standard regimen (Administered as PEP) - Neonate, Maternal Transmission | Phase 3 | Active not recruiting | Jean-Pierre Van geertruyden | 359 | 2025-06-23 | 2026-01-30 |
| Mpox Comprehensive Assessment for Responsive Immunisation in Emergency Outbreaks ELISA, Lateral flow assay - Mpox | Not applicable | Recruiting | University of Birmingham | 650 | 2025-02-05 | 2025-03-20 |
| Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX) Viral genomic, Untargeted Metabolomics - Monkeypox, MPOX | Recruiting | Hospital Israelita Albert Einstein | 80 | 2024-07-16 | 2024-07-17 | |
| A Study to Investigate The Safety, Tolerability, And Immune Response of a Range of Doses of mRNA-1769 Compared With Placebo in Healthy Participants From ≥18 Years of Age to <50 Years of Age mRNA-1769, Placebo - Smallpox, Mpox | Phase 1 / Phase 2 | Completed | ModernaTX, Inc. | 351 | 2023-08-15 | 2025-07-16 |
| Monkeypox, Biology, Outcome, Transmission and Epidemiology -Prospective Follow-up of High-risk Contacts Mpox | Completed | Institute of Tropical Medicine, Belgium | 257 | 2023-05-22 | 2025-05-07 | |
| Assessment of the Efficacy and Safety of Tecovirimat in Patients With Monkeypox Virus Disease Tecovirimat, Placebo - Monkeypox, Mpox | Phase 3 | Active not recruiting | ANRS, Emerging Infectious Diseases | 480 | 2023-03-03 | 2026-05-26 |
| New York City Observational Study of Mpox Immunity Monkeypox, Mpox | Enrolling by invitation | NYU Langone Health | 188 | 2022-11-11 | 2026-08-27 | |
| Break-through Infection Following Mpox vaccinatIon Mpox Vaccine - Mpox | Completed | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 3125 | 2022-09-12 | 2024-06-06 | |
| Study of Tecovirimat for Human Mpox Virus Tecovirimat Oral Capsule, Placebo for Tecovirimat, Tecovirimat Oral Capsule (Open Label) - MPOX | Phase 3 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 719 | 2022-09-08 | 2026-06-23 |
Mpox, Monkeypox (12) · Smallpox (2)
Animal Diseases (12) · DNA Virus Infections (12) · Infections (12) · Poxviridae Infections (12) · Primate Diseases (12) · Rodent Diseases (12) · Virus Diseases (12)
tecovirimat (2) · Smallpox Vaccine (1) · smallpox vaccine LC16m8 (1)
Institute of Tropical Medicine, Belgium (2) · ANRS, Emerging Infectious Diseases (1) · Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia (1) · Hospital Israelita Albert Einstein (1) · International Vaccine Institute (1) · Jean-Pierre Van geertruyden (1) · ModernaTX, Inc. (1) · NYU Langone Health (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Universitaire Ziekenhuizen KU Leuven (1) · University of Birmingham (1)
Democratic Republic of the Congo (5) · Brazil (3) · Argentina (2) · Peru (2) · United States (2) · Chile (1) · Mexico (1) · Panama (1) · Rwanda (1) · Spain (1) · Switzerland (1) · Thailand (1) · United Kingdom (1)
Angelica Kottkamp, MD (1) · Christopher Green (1) · Florian Marks (1) · Henrique Fonseca (1) · Jean Jacques Muyembe (1) · Laurens Liesenborghs, Prof. (1) · Norio Ohmagari (1) · Timothy Wilkin, MD, MPH (1) · Yazdan Yazdapanah, Pr. (1)
PMID 40162783, PMID 40245474, PMID 41688920, PMID 41740032, PMID 42521300