A Prospective Trial of a Novel Antimicrobial Solution to Reduce Infections After Ureteroscopy
Related Papers Related Patents Related Grants Related Experts
All trials for Kidney Stone All trials for Infection All trials of antimicrobial irrigation
-Summary
Ureteroscopy is the most common surgical treatment for kidney stones. Although rare, sepsis after ureteroscopy can be a life-threatening complication, occuring in <3% of patients. There are several risk factors for sepsis including history of positive urine culture, pre-existing ureteral stent, or patients with chronic catheters/tubes. We want to study if an antimicrobial solution with chlorhexidine can prevent infections if instilled into the kidney prior to starting ureteroscopy.
Expand all sections · Collapse all
+Arms and interventions
| Arm | Type | Interventions | Description |
|---|
| Observational | | Drug: antimicrobial irrigation | Treatment with antimicrobial solution |
- antimicrobial irrigation (Drug): antimicrobial irrigation to be used with ureteroscopy
+Outcome measures
Primary outcomes
- Emergency room visits [90 days]: compare rates of ED visits in the prospective cohort to historic controls
Secondary outcomes
- allergic reaction [30 days]: any reactions to the antimicrobial solution
+Eligibility
Sex: All, ages: 18 Years to any
Inclusion Criteria:
* candidate for ureteroscopic stone removal
Exclusion Criteria:
* < 18 years old
* women who are pregnant or breast feeding
+Publications
- CDC: Summary of Recommendations. Infection Control 2024. Available at: https://www.cdc.gov/infection-control/hcp/cauti/summary-of-recommendations.html, accessed July 24, 2024. 2. Anon: Reducing unnecessary urinary catheter use and other strategies to prevent catheter-associated urinary tract infection: an integrative review | BMJ Quality & Safety. Available at: https://qualitysafety.bmj.com/content/23/4/277, accessed May 15, 2025. 3. Anon: Chlorhexidine Irrigation to Reduce Urinary Tract Infections in Patients with Bladder Cancer Undergoing Radical Cystectomy - NCI. 2016. Available at: https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2024-06347, accessed May 15, 2025. 4. Anon: Bladder instillation with Irrisept in Urinary Retention and Neurogenic Bladder - Clinical Trials Registry - ICH GCP. Available at: https://ichgcp.net/clinical-trials-registry/NCT06163469, accessed May 15, 2025.
- Atkins L, Sallis A, Chadborn T, Shaw K, Schneider A, Hopkins S, Bunten A, Michie S, Lorencatto F. Reducing catheter-associated urinary tract infections: a systematic review of barriers and facilitators and strategic behavioural analysis of interventions. Implement Sci. 2020 Jul 6;15(1):44. doi: 10.1186/s13012-020-01001-2. PMID 32624002
- Marschall J, Carpenter CR, Fowler S, Trautner BW; CDC Prevention Epicenters Program. Antibiotic prophylaxis for urinary tract infections after removal of urinary catheter: meta-analysis. BMJ. 2013 Jun 11;346:f3147. doi: 10.1136/bmj.f3147. PMID 23757735